Cell-kinetic investigations in the operated rat stomach to show the influence of duodenogastric reflux. An experimental long-term study.

In has been proven in our own studies that the frequency of carcinoma is closely correlated with the varying intensity of duodenogastric reflux occurring as a result of surgery. Now it was our objective to provide information regarding the changes in cell proliferation kinetics in support of the already established relation, toward which end we conducted an additional autoradiographic study on the gastric mucosa of the same operated animals. Five different operative procedures were performed on the stomachs of 265 female Wistar rats. 3H-Thymidine was used for labeling. Comparison of the labeling rates with the type of operative procedure used revealed an average labeling value typical for each particular procedure. It became evident that increased reflux quite obviously leads to an increase in cell proliferation.