Literature DB >> 658780

Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.

G Claeson, L Aurell, P Friberger, S Gustavsson, G Karlsson.   

Abstract

Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates for kallikreins and urokinase are given.

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Year:  1978        PMID： 658780     DOI： 10.1159/000214236

Source DB:  PubMed          Journal:  Haemostasis        ISSN： 0301-0147


  8 in total

1.  A specific inhibitor of mammalian kallikrein, Phe-Phe-Arg-chloromethyl ketone, inhibits the production of vasoactive substances from trout plasma by kallikrein and blocks endogenous kallikrein-like activity in trout gills.

Authors:  D W Lipke; K R Olson
Journal:  Fish Physiol Biochem       Date:  1992-12       Impact factor: 2.794

2.  Reagents for reversible coupling of proteins to the active centres of trypsin-like serine proteinases.

Authors:  S B Kalindjian; R A Smith
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857

3.  Demonstration of extracellular chymotrypsin-like activity from various Legionella species.

Authors:  B P Berdal; O Olsvik; S Myhre; T Omland
Journal:  J Clin Microbiol       Date:  1982-09       Impact factor: 5.948

4.  Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen.

Authors:  F S Markland; C Kettner; S Schiffman; E Shaw; S S Bajwa; K N Reddy; H Kirakossian; G B Patkos; I Theodor; H Pirkle
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

5.  Peptide thioesters and 4-nitroanilides as substrates for porcine pancreatic kallikrein.

Authors:  J C Powers; B J McRae; T Tanaka; K Cho; R R Cook
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

6.  Amelioration of immune complex-mediated glomerulonephritis by synthetic protease inhibitors.

Authors:  J C Jennette; R R Tidwell; J D Geratz; D H Bing; R J Falk
Journal:  Am J Pathol       Date:  1987-06       Impact factor: 4.307

7.  Plasminogen activator in cultured Lewis lung carcinoma cells measured by chromogenic substrate assay.

Authors:  P Whur; M Magudia; J Boston; J Lockwood; D C Williams
Journal:  Br J Cancer       Date:  1980-08       Impact factor: 7.640

8.  The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels.

Authors:  Rossana García-Fernández; Steve Peigneur; Tirso Pons; Carlos Alvarez; Lidice González; María A Chávez; Jan Tytgat
Journal:  Toxins (Basel)       Date:  2016-04-13       Impact factor: 4.546
  8 in total

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