Literature DB >> 658771

Motilin release in the pig.

I M Modlin, P Mitznegg, S R Bloom.   

Abstract

Motilin is found in the upper intestine of pig and man and in man is released by acid. A similar release by acid has now been found in the pig and is associated with markedly reduced immunostainable motilin in the upper small intestine. Clamping the arteries and veins to the stimulated segment immediately reversed the rise of plasma motilin, indicating the motilin release to be an entirely local phenomenon. The apparent half life of endogenous motilin was 3.9 minutes. No release of motilin was seen after a meal and the possible physiological role of motilin thus remains speculative.

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Year:  1978        PMID： 658771      PMCID： PMC1412103          DOI： 10.1136/gut.19.5.399

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  6 in total

1.  Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.

Authors:  H Ruppin; S Domschke; W Domschke; E Wünsch; E Jaeger; L Demling
Journal:  Scand J Gastroenterol       Date:  1975       Impact factor: 2.423

2.  Radioimmunoassay for motilin.

Authors:  J R Dryburgh; J C Brown
Journal:  Gastroenterology       Date:  1975-05       Impact factor: 22.682

3.  Measurement of human plasma motilin.

Authors:  S R Bloom; P Mitznegg; M G Bryant
Journal:  Scand J Gastroenterol Suppl       Date:  1976

4.  Pharmacokinetics of motilin in man.

Authors:  P Mitznegg; S R Bloom; W Domschke; S Domschke; E Wuensch; L Demling
Journal:  Gastroenterology       Date:  1977-03       Impact factor: 22.682

5.  Enterochromaffin cells of the mammalian small intestine as the source of motilin.

Authors:  A G Pearse; J M Polak; S R Bloom; C Adams; J R Dryburgh; J C Brown
Journal:  Virchows Arch B Cell Pathol       Date:  1974

6.  Release of motilin after duodenal acidification.

Authors:  P Mitznegg; S R Bloom; W Domschke; S Domschke; E Wunsch; L Demling
Journal:  Lancet       Date:  1976-04-24       Impact factor: 79.321
  6 in total
  3 in total

1.  Effects of somatostatin prophylaxis after pylorus-preserving pancreaticoduodenectomy: increased delayed gastric emptying and reduced plasma motilin.

Authors:  Yan-Shen Shan; Edgar D Sy; Mei-Ling Tsai; Li-Ying Tang; P Shirley Li; Pin-Wen Lin
Journal:  World J Surg       Date:  2005-10       Impact factor: 3.352

2.  Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function.

Authors:  Ingrid M C Kamerling; Aernout D van Haarst; Jacobus Burggraaf; Rik C Schoemaker; Marieke L de Kam; Hartmut Heinzerling; Adam F Cohen; Ad A M Masclee
Journal:  Br J Clin Pharmacol       Date:  2004-04       Impact factor: 4.335

3.  Immunocytological evidence of motilin- and secretin-containing cells in the human fetal gastro-entero-pancreatic system.

Authors:  P Leduque; C Paulin; J A Chayvialle; P M Dubois
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249
  3 in total

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