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Literature DB >> 6587378

Complete amino acid sequence of human plasma beta 2-glycoprotein I.

Abstract

We have determined the complete amino acid sequence of beta 2-glycoprotein I (Mr, congruent to 50,000), a human plasma protein that is associated with lipids and binds to platelets but whose function is not yet known. The protein consists of 326 amino acids and has five attached glucosamine-containing oligosaccharides. The protein is rich in cysteine and proline, and the sequence is notable for the frequent occurrence of Cys-Pro linkages at regular intervals. Computerized analysis of the sequence reveals five consecutive homologous segments in which cysteine, proline, and tryptophan appear to be highly conserved. This suggests that beta 2-glycoprotein I may have evolved by repeated duplications of a gene coding for a 60-amino acid segment of protein.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6587378 PMCID： PMC345274 DOI： 10.1073/pnas.81.12.3640

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

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Authors: N HEIMBURGER; K HEIDE; H HAUPT; H E SCHULTZE
Journal: Clin Chim Acta Date: 1964-10 Impact factor: 3.786

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Journal: FEBS Lett Date: 1979-06-01 Impact factor: 4.124

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Authors: J S Finlayson; J F Mushinski
Journal: Biochim Biophys Acta Date: 1967-12-12

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Journal: Humangenetik Date: 1969

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Authors: I Schousboe
Journal: Biochim Biophys Acta Date: 1979-08-28

6. Similar amino acid sequences: chance or common ancestry?

Authors: R F Doolittle
Journal: Science Date: 1981-10-09 Impact factor: 47.728

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Authors: I Schousboe
Journal: Thromb Res Date: 1980 Jul 1-15 Impact factor: 3.944

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Authors: Y Nakaya; E J Schaefer; H B Brewer
Journal: Biochem Biophys Res Commun Date: 1980-08-14 Impact factor: 3.575

9. Purification of glycopeptides of human ceruloplasmin and immunoglobulin D by high-pressure liquid chromatography.

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Journal: Anal Biochem Date: 1982-07-01 Impact factor: 3.365

10. Evidence of normal functional levels of activated protein C inhibitor in combined Factor V/VIII deficiency disease.

Authors: W M Canfield; W Kisiel
Journal: J Clin Invest Date: 1982-12 Impact factor: 14.808

72 in total

1. Immunoreactivity and avidity of IgG anti-β2-glycoprotein I antibodies from patients with autoimmune diseases to different peptide clusters of β2-glycoprotein I.

Authors: A Artenjak; I Locatelli; H Brelih; D M Simonič; Z Ulcova-Gallova; J Swadzba; J Musial; T Iwaniec; L Stojanovich; F Conti; G Valesini; T Avčin; J W Cohen Tervaert; Y Shoenfeld; M Blank; A Ambrožič; S Sodin-Semrl; B Božič; S Čučnik
Journal: Immunol Res Date: 2015-02 Impact factor: 2.829

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Authors: T A Brighton; Y P Dai; P J Hogg; C N Chesterman
Journal: Biochem J Date: 1999-05-15 Impact factor: 3.857

Review 3. Antiphospholipid syndrome: laboratory testing and diagnostic strategies.

Authors: Thomas L Ortel
Journal: Am J Hematol Date: 2012-03-31 Impact factor: 10.047

4. Anti-β2 glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors: apolipoprotein E receptor 2' and glycoprotein I bα.

Authors: Wenjing Zhang; Fei Gao; Donghe Lu; Na Sun; Xiaoxue Yin; Meili Jin; Yanhong Liu
Journal: Front Med Date: 2015-11-30 Impact factor: 4.592

5. Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity.

Authors: William E Ruff; Carina Dehner; Woo J Kim; Odelya Pagovich; Cassyanne L Aguiar; Andrew T Yu; Alexander S Roth; Silvio Manfredo Vieira; Christina Kriegel; Olamide Adeniyi; Melissa J Mulla; Vikki M Abrahams; William W Kwok; Ruth Nussinov; Doruk Erkan; Andrew L Goodman; Martin A Kriegel
Journal: Cell Host Microbe Date: 2019-06-18 Impact factor: 21.023

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Authors: M Hessing
Journal: Biochem J Date: 1991-08-01 Impact factor: 3.857

7. Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide.

Authors: T S Lieu; M M Newkirk; J D Capra; R D Sontheimer
Journal: J Clin Invest Date: 1988-07 Impact factor: 14.808