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Literature DB >> 658632

Insulin receptors on monocytes of young healthy persons correlated with glucose tolerance and insulin sensitivity.

Abstract

We have studied in normal man the interrelationships between insulin binding to monocytes, glucose tolerance and insulin sensitivity. In 25 young healthy persons we found a significant positive correlation between insulin binding and glucose disappearance rate both after glucose (R = 0.68, p less than 0.001) and insulin (R = 0.49, p less than 0.02) given intravenously.

Entities: Chemical Disease Gene Species

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Year: 1978 PMID： 658632 DOI： 10.1007/BF00429775

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

19 in total

1. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus.

Authors: K LUNDBAEK
Journal: Br Med J Date: 1962-06-02

2. Receptor-binding assay of chemically modified insulins. Comparison with in vitro and in vivo bioassays.

Authors: P Freychet; D Brandenburg; A Wollmer
Journal: Diabetologia Date: 1974-02 Impact factor: 10.122

3. Characteristics of the human lymphocyte insulin receptor.

Authors: J R Gavin; P Gorden; J Roth; J A Archer; D N Buell
Journal: J Biol Chem Date: 1973-03-25 Impact factor: 5.157

4. Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes.

Authors: P Freychet; J Roth; D M Neville
Journal: Biochem Biophys Res Commun Date: 1971-04-16 Impact factor: 3.575

5. The significance and interpretation of mildly abnormal oral glucose tolerance.

Authors: F P Alford; F I Martin; M J Pearson
Journal: Diabetologia Date: 1971-06 Impact factor: 10.122

6. The monocyte as a model for the study of insulin receptors in man.

Authors: H Beck-Nielsen; O Pedersen; K Kragballe; N S Sorensen
Journal: Diabetologia Date: 1977-12 Impact factor: 10.122

7. Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.

Authors: J M Olefsky
Journal: J Clin Invest Date: 1976-05 Impact factor: 14.808

8. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

Authors: J R Gavin; J Roth; D M Neville; P de Meyts; D N Buell
Journal: Proc Natl Acad Sci U S A Date: 1974-01 Impact factor: 11.205

9. Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects.

Authors: L C Harrison; F I Martin; R A Melick
Journal: J Clin Invest Date: 1976-12 Impact factor: 14.808

10. Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

Authors: R S Bar; P Gorden; J Roth; C R Kahn; P De Meyts
Journal: J Clin Invest Date: 1976-11 Impact factor: 14.808

10 in total

10. Residual B-cell function in type 1 (insulin-dependent) diabetes mellitus: its relation to clinical and metabolic features.

Authors: E Bonora; C Coscelli; U Butturini
Journal: Acta Diabetol Lat Date: 1984 Oct-Dec

10 in total

Insulin receptors on monocytes of young healthy persons correlated with glucose tolerance and insulin sensitivity.

1. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus.

2. Receptor-binding assay of chemically modified insulins. Comparison with in vitro and in vivo bioassays.

3. Characteristics of the human lymphocyte insulin receptor.

4. Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes.

5. The significance and interpretation of mildly abnormal oral glucose tolerance.

6. The monocyte as a model for the study of insulin receptors in man.

7. Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.

8. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

9. Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects.

10. Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

1. Effects of diet on the cellular insulin binding and the insulin sensitivity in young healthy subjects.

2. Insulin binding to erythrocytes in hyperinsulinemic patients with precirrhotic hemochromatosis and cirrhosis.

3. Conditioning causes an increase in glucose transporter-4 levels in mononuclear cells in sled dogs.

4. Reduced insulin binding to hepatic plasma membranes in D-galactosamine-treated rats.

5. Erythrocyte insulin receptors remain intact through three days of storage.

6. Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients.

7. Dietary guar gum supplementation does not modify insulin resistance in gross obesity.

8. Diabetes in chronic alcoholic pancreatitis. Role of residual beta cell function and insulin resistance.

9. Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and postreceptor defect.

10. Residual B-cell function in type 1 (insulin-dependent) diabetes mellitus: its relation to clinical and metabolic features.