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Literature DB >> 6585308

Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins.

Abstract

The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE2, 15(S),15-methyl PGE2, PGE1 and PGE2 all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.

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Year: 1984 PMID： 6585308 DOI： 10.1016/0014-5793(84)80336-1

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

9 in total

1. Glycogenolytic and haemodynamic responses to heat-aggregated immunoglobulin G and prostaglandin E2 in the perfused rat liver.

Authors: D B Buxton; R A Fisher; D L Briseno; D J Hanahan; M S Olson
Journal: Biochem J Date: 1987-04-15 Impact factor: 3.857

8. Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor.

Authors: J G Altin; F L Bygrave
Journal: Biochem J Date: 1988-02-01 Impact factor: 3.857

9. Indomethacin treatment causes loss of insulin action in rats: involvement of prostaglandins in the mechanism of insulin action.

Authors: H K Wasner; S Weber; H J Partke; H Amini-Hadi-Kiashar
Journal: Acta Diabetol Date: 1994-12 Impact factor: 4.280

9 in total

Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins.

1. Glycogenolytic and haemodynamic responses to heat-aggregated immunoglobulin G and prostaglandin E2 in the perfused rat liver.

2. Structural specificity for prostaglandin effects on hepatocyte glycogenolysis.

3. Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria.

4. Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes.

5. Effect of nonsteroidal anti-inflammatory drugs on glycogenolysis in isolated hepatocytes.

6. Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids.

7. Effect of hydroxycobalamin[c-lactam] on propionate and carnitine metabolism in the rat.

8. Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor.

9. Indomethacin treatment causes loss of insulin action in rats: involvement of prostaglandins in the mechanism of insulin action.