Literature DB >> 6584913

Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses.

T Moran, Y C Liu, J L Schulman, C A Bona.   

Abstract

A monoclonal antibody specific for the hemagglutinin (HA) of influenza A X-31 (H3N2) virus (X-31) was obtained during a fusion of spleen cells from a BALB/c mouse immunized with influenza A/PR/8/34 (H1N1) virus (PR8). This monoclonal antibody (Py206) shares crossreactive idiotopes expressed on several monoclonal antibodies specific for PR8 HA and X-31 HA as well as an individual idiotope shared with one monoclonal antibody specific for X-31 HA. The presence of shared idiotypy among antibodies of such diverse binding specificities may result from regulation by idiotype-specific T cells. In addition, the results suggest that, in contrast to the diversity of paratypes expressed, relatively few germ-line variable region genes may be used in the antibody response to influenza A virus antigens.

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Year:  1984        PMID： 6584913      PMCID： PMC345010          DOI： 10.1073/pnas.81.6.1809

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

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Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205

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Journal:  FEBS Lett       Date:  1973-05-01       Impact factor: 4.124

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Journal:  Virology       Date:  1980-04-30       Impact factor: 3.616

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Journal:  J Immunol       Date:  1981-06       Impact factor: 5.422

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Journal:  J Infect Dis       Date:  1983-11       Impact factor: 5.226

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Journal:  J Exp Med       Date:  1975-07-01       Impact factor: 14.307

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Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307
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  10 in total

1.  Shared idiotopes among antibodies encoded by heavy-chain variable region (VH) gene members of the J558 VH family as basis for cross-reactive regulation of clones with different antigen specificity.

Authors:  C Victor-Kobrin; T Manser; T M Moran; T Imanishi-Kari; M Gefter; C A Bona
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

2.  Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Authors:  Florian Krammer; Rong Hai; Mark Yondola; Gene S Tan; Victor H Leyva-Grado; Alex B Ryder; Matthew S Miller; John K Rose; Peter Palese; Adolfo García-Sastre; Randy A Albrecht
Journal:  J Virol       Date:  2014-01-08       Impact factor: 5.103

3.  Nucleotide changes in sequential variants of influenza virus hemagglutinin genes and molecular structures of corresponding monoclonal antibodies specific for each variant.

Authors:  K Meek; B Johansson; J Schulman; C Bona; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

4.  TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.

Authors:  Akihiro Yoshizawa; Kevin Bi; Derin B Keskin; Guanglan Zhang; Bruce Reinhold; Ellis L Reinherz
Journal:  Eur J Immunol       Date:  2017-09-29       Impact factor: 5.532

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Authors:  E M Anders; G P Kapaklis-Deliyannis; D O White
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

6.  Recognition of interspecies hybrid class I histocompatibility antigens by antigen-specific cytolytic T lymphocytes.

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Journal:  Clin Diagn Lab Immunol       Date:  1995-07

8.  Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes.

Authors:  I N Mbawuike; H R Six; T R Cate; R B Couch
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

9.  A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo.

Authors:  Gene S Tan; Florian Krammer; Dirk Eggink; Alita Kongchanagul; Thomas M Moran; Peter Palese
Journal:  J Virol       Date:  2012-04-04       Impact factor: 5.103

10.  A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

Authors:  Florian Krammer; Irina Margine; Gene S Tan; Natalie Pica; Jens C Krause; Peter Palese
Journal:  PLoS One       Date:  2012-08-23       Impact factor: 3.240
  10 in total

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