| Literature DB >> 6584312 |
L B Natan, P Chaillet, J M Lecomte, H Marçais, G Uchida, J Costentin.
Abstract
In the mouse 'behavioral despair' test the immobility time was shortened by [D-Ala2,Met5]enkephalin at doses which did not modify locomotor activity. Similarly, the inhibitors of the enzymes degrading enkephalins, thiorphan and/or bestatin were effective. Their effect was antagonized by naloxone. We conclude that endogenous enkephalins are implicated in the 'behavioral despair' test.Entities:
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Year: 1984 PMID： 6584312 DOI： 10.1016/0014-2999(84)90464-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432