Literature DB >> 6584201

A high-resolution study of chromosome changes in a human prostatic carcinoma cell line (LNCaP).

Z Gibas, R Becher, E Kawinski, J Horoszewicz, A A Sandberg.   

Abstract

A high-resolution study of chromosomal rearrangements in a human prostatic cancer cell line, LNCaP, has been performed. The cytogenetic analysis revealed a pseudodiploid karyotype and the presence of seven marker chromosomes resulting from five aberrational events. The analysis of four clones derived from the original line showed a near-tetraploid chromosome number and the presence of the same seven markers observed in the original line. This is the first complete description of karyotypic rearrangements in a prostatic cancer cell line.

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Year:  1984        PMID： 6584201     DOI： 10.1016/0165-4608(84)90020-7

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  17 in total

1.  Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis.

Authors:  B Beheshti; P C Park; J M Sweet; J Trachtenberg; M A Jewett; J A Squire
Journal:  Neoplasia       Date:  2001 Jan-Feb       Impact factor: 5.715

2.  Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer cell lines by sequential giemsa banding and spectral karyotyping.

Authors:  B Beheshti; J Karaskova; P C Park; J A Squire; B G Beatty
Journal:  Mol Diagn       Date:  2000-03

3.  Spontaneous phenotypic and karyotypic progression in the SV40 transfected cell line SVG during prolonged passage in vitro.

Authors:  P Davey; A M Rauth; L Mason; L Addy
Journal:  J Neurooncol       Date:  1990-02       Impact factor: 4.130

4.  Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.

Authors:  L-Y Wang; H-J Kung
Journal:  Oncogene       Date:  2011-10-10       Impact factor: 9.867

5.  Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines.

Authors:  Danielle M Pastor; Lisa S Poritz; Thomas L Olson; Christina L Kline; Leonard R Harris; Walter A Koltun; Vernon M Chinchilli; Rosalyn B Irby
Journal:  Int J Clin Exp Med       Date:  2010-02-22

6.  Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP.

Authors:  J J König; E Kamst; A Hagemeijer; J C Romijn; J Horoszewicz; F H Schröder
Journal:  Urol Res       Date:  1989

7.  A Mutation in the Carbohydrate Recognition Domain Drives a Phenotypic Switch in the Role of Galectin-7 in Prostate Cancer.

Authors:  Marilyne Labrie; Maria Vladoiu; Bruno G Leclerc; Andrée-Anne Grosset; Louis Gaboury; John Stagg; Yves St-Pierre
Journal:  PLoS One       Date:  2015-07-13       Impact factor: 3.240

8.  Chromosome study of five cancers of the prostate.

Authors:  N B Atkin; M C Baker
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

9.  A dual-reporter, diagnostic vector for prostate cancer detection and tumor imaging.

Authors:  J R Richter; M Mahoney; J M Warram; S Samuel; K R Zinn
Journal:  Gene Ther       Date:  2014-07-24       Impact factor: 5.250

10.  Allelic loss of chromosomes 16q and 10q in human prostate cancer.

Authors:  B S Carter; C M Ewing; W S Ward; B F Treiger; T W Aalders; J A Schalken; J I Epstein; W B Isaacs
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205
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