Literature DB >> 6584105

Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers.

P Ghezzi, M Bianchi, A Mantovani, F Spreafico, M Salmona.   

Abstract

Administration to mice of either interferon (IFN) or IFN inducers resulted in a marked increase of xanthine oxidase (XO) activity in different organs. Dose response studies revealed that serum XO was increased by administration of polyinosylic-polycyticylic acid (poly I-C) at doses as low as 0.1 mg/kg. In view of the well known ability of XO to generate superoxide radicals it is suggested that its induction might play a role in several biological effects of IFN.

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Year:  1984        PMID： 6584105     DOI： 10.1016/0006-291x(84)91630-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

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2.  Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo.

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9.  Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine.

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Review 10.  A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase.

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Journal:  Histochem J       Date:  1994-12
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