| Literature DB >> 6583846 |
R H Chou, P A Chervenick, D R Barch.
Abstract
A 60-kilodalton protein was identified in chromatin digested by micrococcal nuclease during retinoic acid-induced differentiation of human leukemia (HL-60) cells to mature-like granulocytes. The protein was not detected in a retinoic acid-resistant variant of the HL-60 cell line treated with retinoic acid, in HL-60 cells induced with dimethyl sulfoxide, or in normal human granulocytes. This protein may have an important role in the regulation of retinoic acid-induced leukemic cell differentiation.Entities:
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Year: 1984 PMID： 6583846 DOI： 10.1126/science.6583846
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728