Literature DB >> 6583195

Safety and tolerance comparison of imipenem-cilastatin to cephalothin and cefazolin.

G B Calandra, F M Ricci, C Wang, K R Brown.   

Abstract

Imipenem-cilastatin was compared, in two multicentre clinical trials, with cefazolin or cephalothin, in their efficacy, safety, and tolerance. Safety and tolerance for imipenem-cilastatin was similar to that of these two cephalosporins. There were more transient liver function test changes in the imipenem-cilastatin group, but the frequency was similar to that for beta-lactams in general. There were similar numbers of cases of transient neutropenia in each group. Clinical side effects were few for the treatment groups and all drugs were well tolerated.

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Year:  1983        PMID： 6583195     DOI： 10.1093/jac/12.suppl_d.125

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  7 in total

Review 1.  Comparative pharmacokinetics of the carbapenems: clinical implications.

Authors:  J W Mouton; D J Touzw; A M Horrevorts; A A Vinks
Journal:  Clin Pharmacokinet       Date:  2000-09       Impact factor: 6.447

2.  Imipenem/cilastatin.

Authors:  M Barza
Journal:  Eur J Clin Microbiol       Date:  1984-10       Impact factor: 3.267

3.  A multiclinic randomized study of the comparative efficacy, safety and tolerance of imipenem/cilastatin and moxalactam.

Authors:  G B Calandra; M Hesney; C Grad
Journal:  Eur J Clin Microbiol       Date:  1984-10       Impact factor: 3.267

Review 4.  Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  S P Clissold; P A Todd; D M Campoli-Richards
Journal:  Drugs       Date:  1987-03       Impact factor: 9.546

5.  Disposition of radiolabeled imipenem and cilastatin in normal human volunteers.

Authors:  S R Norrby; J D Rogers; F Ferber; K H Jones; A G Zacchei; L L Weidner; J L Demetriades; D A Gravallese; J Y Hsieh
Journal:  Antimicrob Agents Chemother       Date:  1984-11       Impact factor: 5.191

6.  [Calculated initial chemotherapy in mechanically-ventilated postoperative patients with peritonitis, sepsis and pneumonia].

Authors:  G Hünefeld; H Weissbrodt; H Aebert; H Bunzendahl
Journal:  Infection       Date:  1986       Impact factor: 3.553

7.  A novel analytical method to assess the effect of imipenem/cilastatin on liver function laboratory indexes in Chinese underage inpatients: Probability distribution curve.

Authors:  Le Zou; Fanqi Meng; Weici Wang; Qianqian Ye; Lin Hu; Taoming Li; Tao Yin
Journal:  PLoS One       Date:  2019-10-24       Impact factor: 3.240
  7 in total

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