Literature DB >> 658310

A new antisickling agent: in vitro studies of its effect on S/S erythrocytes and on hemoglobin S.

P K Adhikary, J K Haynes, H L Patthey, R S Rhodes.   

Abstract

2-(benzoylamino) pyridinium benzoate (BAPB) has exhibited an antisickling effect with homozygous S/S erythrocytes in vitro. This study suggests that BAPB prevents sickling by inhibiting the gelation of hemoglobin S.

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Year:  1978        PMID： 658310     DOI： 10.1007/BF01947338

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  The benzoylation of 2-aminopyridine.

Authors:  E H HUNTRESS; H C WALTER
Journal:  J Org Chem       Date:  1948-09       Impact factor: 4.354

2.  Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation.

Authors:  K SINGER; A I CHERNOFF; L SINGER
Journal:  Blood       Date:  1951-05       Impact factor: 22.113

3.  The fine structure of sickled hemoglobin in situ.

Authors:  J G White
Journal:  Blood       Date:  1968-05       Impact factor: 22.113

4.  Methylisocyanate as an antisickling agent and its reaction with hemoglobin S.

Authors:  C K Lee
Journal:  J Biol Chem       Date:  1976-10-25       Impact factor: 5.157

5.  Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro.

Authors:  A Cerami; J M Manning
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

6.  Gels of normal and sickled hemoglobin: comparative study.

Authors:  J G White; B Heagan
Journal:  J Exp Med       Date:  1970-06-01       Impact factor: 14.307
  6 in total

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