Literature DB >> 658293

Specific in vivo binding of d-LSD in rat brain.

K Kräuchi, H Feer, M Lichtsteiner, A Wirz-Justice.   

Abstract

A reproducible in vivo d-LSD binding method in rat brain is described, with high affinity (Kd of 5 pmoles/g wet wt), stereospecificity (d- vs. 1-LSD) and regional selectivity. It may be a useful adjunct to in vitro methods for measuring changes in turnover at the synaptic level related to the intact receptor.

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Year:  1978        PMID： 658293     DOI： 10.1007/BF01947309

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Stereospecific receptor sites for d-lysergic acid diethylamide in rat brain: effects of neurotransmitters, amine antagonists, and other psychotropic drugs.

Authors:  R A Lovell; D X Freedman
Journal:  Mol Pharmacol       Date:  1976-07       Impact factor: 4.436

2.  Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.

Authors:  J P Bennett; S H Snyder
Journal:  Mol Pharmacol       Date:  1976-05       Impact factor: 4.436

3.  Comparison of in vivo and in vitro parameters of opiate receptor binding in naive and tolerant dependent rodents.

Authors:  V Höllt; J Dum; J Bläsig; P Schubert; A Herz
Journal:  Life Sci       Date:  1975-06-15       Impact factor: 5.037

4.  Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain.

Authors:  D R Burt; I Creese; S H Snyder
Journal:  Mol Pharmacol       Date:  1976-07       Impact factor: 4.436

5.  The demonstration in vivo of specific binding sites for neuroleptic drugs in mouse brain.

Authors:  V Höllt; A Czlonkowski; A Herz
Journal:  Brain Res       Date:  1977-07-08       Impact factor: 3.252

6.  Stereospecific binding of D-lysergic acid diethylamide (LSD) to brain membranes: relationship to serotonin receptors.

Authors:  J P Bennett; S H snyder
Journal:  Brain Res       Date:  1975-09-05       Impact factor: 3.252

7.  Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

Authors:  J Glowinski; L L Iversen
Journal:  J Neurochem       Date:  1966-08       Impact factor: 5.372
  7 in total
  1 in total

1.  In vivo 3H-d-LSD binding in small punched out rat brain regions.

Authors:  K Kräuchi; H Feer
Journal:  Experientia       Date:  1980-09-15
  1 in total

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