Literature DB >> 6582907

In vitro sublethal damage repair in tumour subpopulations from a heterogeneous human colon tumour.

J T Leith, A V Vayer, J K De Wyngaert, H Amols, R A Peck, A S Glicksman.   

Abstract

The repair of sublethal radiation damage in two asynchronously growing tumour cell subpopulations (clones A and D) obtained from a single human adenocarcinoma biopsy specimen has been studied. The survival data found after generation of complete survival curves from split dose experiments in which exposures were separated by 3, 6, 12, or 24 h were examined. It was found that the method of performing irradiations (e.g., suspension cultures versus monolayer cultures) affected the shape of the single dose response curves, and as a result the interpretation of the amount of sublethal damage repair occurring after split dose irradiation.

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Year:  1984        PMID： 6582907      PMCID： PMC2149146     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  8 in total

1.  Heterogeneity of tumor cells from a single mouse mammary tumor.

Authors:  D L Dexter; H M Kowalski; B A Blazar; Z Fligiel; R Vogel; G H Heppner
Journal:  Cancer Res       Date:  1978-10       Impact factor: 12.701

2.  Metastasis results from preexisting variant cells within a malignant tumor.

Authors:  I J Fidler; M L Kripke
Journal:  Science       Date:  1977-08-26       Impact factor: 47.728

3.  Clinical and pharmacological implications of cancer cell differentiation and heterogeneity.

Authors:  P Calabresi; D L Dexter; G H Heppner
Journal:  Biochem Pharmacol       Date:  1979-06-15       Impact factor: 5.858

4.  Flow-cytometric demonstration of tumour-cell subpopulations with different DNA content in human colo-rectal carcinoma.

Authors:  S E Petersen; P Bichel; M Lorentzen
Journal:  Eur J Cancer       Date:  1979-04       Impact factor: 9.162

5.  Cell clones with different sensitivity to cytostatic drugs in methylcholanthrene-induced mouse sarcomas.

Authors:  L Håkansson; C Tropé
Journal:  Acta Pathol Microbiol Scand A       Date:  1974-01

6.  Differential RBE values obtained for mammary adenocarcinoma tumor cell subpopulations after 14.8-MeV neutron irradiation.

Authors:  J K DeWyngaert; J T Leith; R A Peck; S F Bliven; E M Zeman; S A Marino; A S Glicksman
Journal:  Radiat Res       Date:  1981-10       Impact factor: 2.841

7.  Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.

Authors:  G H Heppner; D L Dexter; T DeNucci; F R Miller; P Calabresi
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

8.  Heterogeneity of cancer cells from a single human colon carcinoma.

Authors:  D L Dexter; E N Spremulli; Z Fligiel; J A Barbosa; R Vogel; A VanVoorhees; P Calabresi
Journal:  Am J Med       Date:  1981-12       Impact factor: 4.965
  8 in total
  3 in total

1.  Biological heterogeneity and radiation sensitivity of in vitro propagated lung metastatic lines originated from a transplantable squamous cell carcinoma of BALB/c mouse.

Authors:  R J Jamasbi; E H Perkins
Journal:  In Vitro Cell Dev Biol       Date:  1990-03

2.  Time-dependent subpopulation induction in heterogeneous tumors.

Authors:  I Gyori; S Michelson; J Leith
Journal:  Bull Math Biol       Date:  1988       Impact factor: 1.758

3.  Applicability of the linear-quadratic model to single and fractionated radiotherapy schedules: an experimental study.

Authors:  Akifumi Miyakawa; Yuta Shibamoto; Shinya Otsuka; Hiromitsu Iwata
Journal:  J Radiat Res       Date:  2013-12-17       Impact factor: 2.724
  3 in total

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