Literature DB >> 658275

The metabolism of dibenz[b,f]-1,4-oxazepine (CR): in vivo hydroxylation of 10,11-dihydrodibenz[b,f]-1,4-oxazepin-11-(1OH)-one and the NIH shift.

J M Harrison, R J Clarke, T D Inch, D G Upshall.   

Abstract

Studies of the in vivo metabolism of 10,11-dihydrodibenz[b,f]-1,4-oxazepin-11-(1OH)-one (2) specifically deuteriated at C7 implicate an arene oxide intermediate during the conversion to 7-hydroxy-2 (4) as evidenced by the observation of the NIH shift.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 658275     DOI： 10.1007/BF01947265

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

Review 1.  Biological formation and disposition of arene oxides.

Authors:  D M Jerina
Journal:  Lloydia       Date:  1974-06

2.  Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

Authors:  J W Daly; D M Jerina; B Witkop
Journal:  Experientia       Date:  1972-10-15

3.  Migration of deuterium during hydroxylation of aromatic substrates by liver microsomes. I. Influence of ring substitutents.

Authors:  J Daly; D Jerina; B Witkop
Journal:  Arch Biochem Biophys       Date:  1968-11       Impact factor: 4.013

4.  The migration of deuterium during aryl hydroxylation. II. Effect of induction of microsomal hydroxylases with phenobarbital or polycyclic aromatic hydrocarbons.

Authors:  J Daly; D Jerina; J Farnsworth; G Guroff
Journal:  Arch Biochem Biophys       Date:  1969-04       Impact factor: 4.013

5.  Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to arene oxide pathway.

Authors:  J E Tomaszewski; D M Jerina; J W Daly
Journal:  Biochemistry       Date:  1975-05-06       Impact factor: 3.162
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.