Literature DB >> 658257

Effect of variations in temperature on antimuscarinic activity in guinea-pig atria.

C K Li, F Mitchelson.   

Abstract

The characteristics of the antimuscarinic activity of homatropine, gallamine and stercuronium in guinea-pig atria remained constant over the temperature range 22--37 degrees C in that a linear Arunlakshana-Schild plot was obtained with homatropine and nonlinear plots occurred with gallamine or stercuronium. A trend towards higher dose-ratios with reduction in temperature was only significant for gallamine.

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Year:  1978        PMID： 658257     DOI： 10.1007/BF01937009

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  18 in total

1.  Temperature dependence of phenoxybenzamine effects and the adrenoceptor transformation hypothesis.

Authors:  B G Benfey
Journal:  Nature       Date:  1975-08-28       Impact factor: 49.962

2.  A CORRELATION BETWEEN THE BIOLOGICAL ACTIVITY OF ALKYLTRIMETHYLAMMONIUM IONS AND THEIR MODE OF INTERACTION WITH ACETYLCHOLINESTERASE.

Authors:  B BELLEAU; H TANI; F LIE
Journal:  J Am Chem Soc       Date:  1965-05-20       Impact factor: 15.419

3.  A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

Authors:  R B Barlow; K J Berry; P A Glenton; N M Nilolaou; K S Soh
Journal:  Br J Pharmacol       Date:  1976-12       Impact factor: 8.739

4.  The pharmacology of Flaxedil, with observations on certain analogs.

Authors:  W F RIKER; W C WESCOE
Journal:  Ann N Y Acad Sci       Date:  1951-10       Impact factor: 5.691

5.  Effects of sympathetic innervation and temperature on the properties of rat heart adrenoceptors.

Authors:  G Kunos; M Nickerson
Journal:  Br J Pharmacol       Date:  1977-04       Impact factor: 8.739

6.  The effects of three short-acting neuromuscular blocking agents on fast- and slow-contracting muscles of the cat.

Authors:  I G Marshall
Journal:  Eur J Pharmacol       Date:  1973-03       Impact factor: 4.432

7.  Effect of ligands on a discontinuous temperature dependence of the decarbamylation reaction of erythrocyte acetylcholinesterase.

Authors:  B D Roufogalis; E E Quist; V M Wickson
Journal:  Biochim Biophys Acta       Date:  1973-10-10

8.  Temperature-dependent sensitivity of adrenoreceptors in the toad's heart.

Authors:  M N Harri
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1973

9.  Dependence of the transmembraneous penetration rate of an anticholinergic drug on the action potential frequency.

Authors:  G H Reil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977       Impact factor: 3.000

10.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03
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  1 in total

1.  The selective antimuscarinic action of stercuronium.

Authors:  C K Li; F Mitchelson
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739
  1 in total

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