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Literature DB >> 6582473

Perpendicular orientation and directional migration of amphibian neural crest cells in dc electrical fields.

Abstract

The behavior of cultured neural crest cells of Ambystoma mexicanum and Xenopus laevis in dc electrical fields was studied. In fields of 1-5 V/cm, isolated or confluent cells retract both their anode- and cathode-facing margins. Subsequently, the cells elongate, with protrusive activity confined to their narrow ends. In larger fields (greater than or equal to 5 V/cm), protrusions form on the cathode-facing sides of the perpendicularly oriented cells. The cells then begin migrating laterally, perpendicular to their long axes, towards the cathode. We suggest that the perpendicular alignment and cathode-directed migrations result from cytoskeletal changes mediated by modified ion fluxes through the anode-facing (hyperpolarized) and cathode-facing (depolarized) cell membranes. The breaking of cellular confluence in response to dc electric fields is also discussed.

Entities: Species

Mesh：

Year: 1984 PMID： 6582473 PMCID： PMC344630 DOI： 10.1073/pnas.81.1.160

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

Review 1. Cytoplasmic structure and contractility in amoeboid cells.

Authors: D L Taylor; J S Condeelis
Journal: Int Rev Cytol Date: 1979

2. Bioelectricity and regeneration. I. Initiation of frog limb regeneration by minute currents.

Authors: R B Borgens; J W Vanable; L F Jaffe
Journal: J Exp Zool Date: 1977-06

Review 3. Electrical controls of development.

Authors: L F Jaffe; R Nuccitelli
Journal: Annu Rev Biophys Bioeng Date: 1977

4. Effects of electrode placement on stimulation of adult frog limb regeneration.

Authors: S D Smith
Journal: Ann N Y Acad Sci Date: 1974 Impact factor: 5.691

Review 5. Ion channels in development.

Authors: N C Spitzer
Journal: Annu Rev Neurosci Date: 1979 Impact factor: 12.449

Perpendicular orientation and directional migration of amphibian neural crest cells in dc electrical fields.

Review 1. Cytoplasmic structure and contractility in amoeboid cells.

2. Bioelectricity and regeneration. I. Initiation of frog limb regeneration by minute currents.

Review 3. Electrical controls of development.

4. Effects of electrode placement on stimulation of adult frog limb regeneration.

Review 5. Ion channels in development.

6. Embryonic cell motility can be guided by physiological electric fields.

7. Electrophoretic movement and localisation of acetylcholine receptors in the embryonic muscle cell membrane.

8. Analysis of the neural crest ventral pathway using injected tracer cells.

9. Neurites grow faster towards the cathode than the anode in a steady field.

10. Relations between ameboid movement and membrane-controlled electrical currents.

1. Electrotaxis of lung cancer cells in ordered three-dimensional scaffolds.

2. Activity-dependent neuronal cell migration induced by electrical stimulation.

Review 3. Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell.

4. Galvanotactic control of collective cell migration in epithelial monolayers.

5. Dynamic aspects of amphibian neurite growth and the effects of an applied electric field.

6. Optical imaging of cell membrane potential changes induced by applied electric fields.

7. Comments on the use of electromagnetic fields in biological studies.

8. SCHEEPDOG: Programming Electric Cues to Dynamically Herd Large-Scale Cell Migration.

9. Cell shape-dependent rectification of surface receptor transport in a sinusoidal electric field.

10. Lymphocyte electrotaxis in vitro and in vivo.