Literature DB >> 6581831

Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin.

C B Archer, C P Page, W Paul, J Morley, D M MacDonald.   

Abstract

The phospholipid PAF-acether is released from a range of inflammatory cell types and, in experimental animals, has properties appropriate to a mediator of inflammation. We have studied the inflammatory characteristics of intradermally injected PAF-acether in human skin. An early weal and flare response was succeeded, in a proportion of subjects, by an area of late-onset erythema at the site of the resolved weal, reminiscent of the dual response to allergen in sensitized individuals. The time-course and dose-response relationship of the early response has been determined and a synergistic interaction between PAF-acether and prostaglandin E2 established. PAF-acether should therefore be considered as a potential mediator of both acute and persisting inflammation in man.

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Year:  1984        PMID： 6581831     DOI： 10.1111/j.1365-2133.1984.tb07310.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  23 in total

Review 1.  Hypoxia and inflammatory synovitis: observations and speculation.

Authors:  C R Stevens; R B Williams; A J Farrell; D R Blake
Journal:  Ann Rheum Dis       Date:  1991-02       Impact factor: 19.103

Review 2.  PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Authors:  M Koltai; D Hosford; P Guinot; A Esanu; P Braquet
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

Review 3.  Platelet activating factor and asthma.

Authors:  J Morley
Journal:  Agents Actions       Date:  1986-10

4.  Effect of nedocromil sodium on allergen-, PAF-, histamine- and bradykinin-induced airways vasodilatation and pulmonary obstruction in the pig.

Authors:  K Alving; R Matran; J M Lundberg
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

5.  Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation.

Authors:  D G Sciberras; M M Goldenberg; J A Bolognese; I James; N S Baber
Journal:  Br J Clin Pharmacol       Date:  1987-12       Impact factor: 4.335

6.  Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects.

Authors:  N M Roberts; M McCusker; K F Chung; P J Barnes
Journal:  Br J Clin Pharmacol       Date:  1988-07       Impact factor: 4.335

7.  The role of histamine in the acute inflammatory responses to intradermal platelet activating factor.

Authors:  D G Sciberras; S Jordan; D Gill; N S Baber; I James
Journal:  Br J Clin Pharmacol       Date:  1991-07       Impact factor: 4.335

8.  Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.

Authors:  C B Archer; D M MacDonald; J Morley; C P Page; W Paul; S Sanjar
Journal:  Br J Pharmacol       Date:  1985-05       Impact factor: 8.739

9.  Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung.

Authors:  J P Seale; S Nourshargh; P G Hellewell; T J Williams
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

Review 10.  Leukotriene B4 and platelet-activating factor in human skin.

Authors:  L Michel; L Dubertret
Journal:  Arch Dermatol Res       Date:  1992       Impact factor: 3.017
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