Literature DB >> 658148

Evidence for an endogenous factor interfering with 3H-diazepam binding to rat brain membranes.

M Karobath, G Sperk, G Schönbeck.   

Abstract

An in vitro "receptor" binding assay has been used to search for an endogenous compound which possibly interacts with benzodiazepine receptors in brain. Such an endogenous 3H-diazepam binding inhibitory factor (DIF) has been found. This compound is unevenly distributed in brain and in various peripheral organs. The partially purified compound appears to have a low molecular weight (below 500) and is not inactivated by proteolytic enzymes.

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Year:  1978        PMID： 658148     DOI： 10.1016/0014-2999(78)90111-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Competitive inhibition of benzodiazepine binding by fractions from porcine brain.

Authors:  G D Colello; D M Hockenbery; H B Bosmann; S Fuchs; K Folkers
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

2.  Identification of inosine and hypoxanthine as endogenous ligands for the brain benzodiazepine-binding sites.

Authors:  T Asano; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

3.  Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.

Authors:  P Skolnick; P J Syapin; B A Paugh; V Moncada; P J Marangos; S M Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

4.  Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.

Authors:  M Karobath; G Sperk
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

5.  Purification and characterization of tribulin, and endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding.

Authors:  J D Elsworth; D Dewar; V Glover; B L Goodwin; A Clow; M Sandler
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

6.  Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

Authors:  C Braestrup; M Nielsen; C E Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

7.  Isolation and identification in bovine cerebral cortex of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor.

Authors:  C Peña; J H Medina; M L Novas; A C Paladini; E De Robertis
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

8.  The benzodiazepines and inosine antagonize caffeine-induced seizures.

Authors:  P J Marangos; A M Martino; S M Paul; P Skolnick
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

9.  Anticonvulsant doses of inosine result in brain levels sufficient to inhibit [3H] diazepam binding.

Authors:  P J Marangos; E Trams; R L Clark-Rosenberg; S M Paul; P Skolnick
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

Authors:  A Guidotti; C M Forchetti; M G Corda; D Konkel; C D Bennett; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205
  10 in total

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