Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex.

Literature DB >> 658145

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex.

Abstract

The effects of adenosine and some related purines on the K+-induced release of 3H-noradrenaline from rat cerebral cortex slices were determined in a superfusion system. Adenosine and ATP caused a dose-dependent inhibition of 3H-NA release with a maximal effect of 35% at 10(-4) M. Theophylline, 10(-4) M, antagonized the inhibitory effect of adenosine. The results support the hypothesis that at least some of the central stimulant effects of the methylxanthines could be related to blockade of a purinergic inhibitory tone on noradrenergic synaptic output.

Entities: Chemical Species

Mesh：

Substances：

Year: 1978 PMID： 658145 DOI： 10.1016/0014-2999(78)90107-3

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

Keyword Cloud
Cited

19 in total

1. Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture.

Authors: R L MacDonald; J H Skerritt; M A Werz
Journal: J Physiol Date: 1986-01 Impact factor: 5.182

2. Characterization of adenosine receptors in rat brain by (-)[3H]N6-phenylisopropyladenosine.

Authors: U Schwabe; T Trost
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1980-09 Impact factor: 3.000

3. Adenosine analogs mediating depressant effects on synaptic transmission in rat hippocampus: structure-activity relationships for the N6 subregion.

Authors: T V Dunwiddie; T S Worth; R A Olsson
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1986-09 Impact factor: 3.000

4. Adenosine and the endothelium-dependent modulation of 3H-noradrenaline release in the canine pulmonary artery.

Authors: M J Vaz-da-Silva; S Guimarães; D Moura
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1995-12 Impact factor: 3.000

5. Purinoceptor modulation of noradrenaline release in rat tail artery: tonic modulation mediated by inhibitory P2Y- and facilitatory A2A-purinoceptors.

Authors: J Gonçalves; G Queiroz
Journal: Br J Pharmacol Date: 1996-01 Impact factor: 8.739

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex.

1. Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture.

2. Characterization of adenosine receptors in rat brain by (-)[3H]N6-phenylisopropyladenosine.

3. Adenosine analogs mediating depressant effects on synaptic transmission in rat hippocampus: structure-activity relationships for the N6 subregion.

4. Adenosine and the endothelium-dependent modulation of 3H-noradrenaline release in the canine pulmonary artery.

5. Purinoceptor modulation of noradrenaline release in rat tail artery: tonic modulation mediated by inhibitory P2Y- and facilitatory A2A-purinoceptors.

6. Release of norepinephrine and dopamine from brain vesicular preparations: effects of adenosine analogues.

7. Adenosine inhibition of gamma-aminobutyric acid release from slices of rat cerebral cortex.

8. Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.

9. Endogenous adenosine inhibits hippocampal CA1 neurones: further evidence from extra- and intracellular recording.

Review 10. Caffeine and anaerobic performance: ergogenic value and mechanisms of action.