Literature DB >> 658121

Blockade of neuronal tryptamine receptors by metoclopramide.

J R Fozard, A T Mobarok ALI.   

Abstract

Metoclopramide (0.13, 0.51, 2.0 and 8.1 X 10(-6) M) caused parallel, rightward, shifts in the dose response curves to 5-HT on the isolated rabbit heart. A significant straight line relationship was found between log (5-HT dr--1) and log [metoclopramide] (molar) with a slope of 1.08 +/- 0.13 and giving a pA2 value of 7.20. Metoclopramide did not significantly alter responses to noradrenaline and was 575 times less effective as an inhibitor of DMPP than of 5-HT. The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 658121     DOI： 10.1016/0014-2999(78)90228-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  31 in total

Review 1.  Neuropharmacology of emesis in relation to clinical response.

Authors:  B Costall; R J Naylor
Journal:  Br J Cancer Suppl       Date:  1992-12

Review 2.  5-HT3 receptor antagonists and migraine therapy.

Authors:  M D Ferrari
Journal:  J Neurol       Date:  1991       Impact factor: 4.849

3.  Tramadol-induced adrenal insufficiency.

Authors:  Miguel Debono; Sharon Chan; Christen Rolfe; T Hugh Jones
Journal:  Eur J Clin Pharmacol       Date:  2011-01-18       Impact factor: 2.953

4.  The serotonin type 3 receptor antagonist BRL 43694 and nausea and vomiting induced by cisplatin.

Authors:  J Carmichael; B M Cantwell; C M Edwards; W G Rapeport; A L Harris
Journal:  BMJ       Date:  1988-07-09

5.  Interactions of metoclopramide and ergotamine with human 5-HT(3A) receptors and human 5-HT reuptake carriers.

Authors:  Jan Walkembach; Michael Brüss; Bernd W Urban; Martin Barann
Journal:  Br J Pharmacol       Date:  2005-10       Impact factor: 8.739

6.  Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors.

Authors:  A Butler; J M Hill; S J Ireland; C C Jordan; M B Tyers
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

7.  Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors?

Authors:  J Maj; E Chojnacka-Wójcik; A Kłodzińska; A Dereń; E Moryl
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

8.  The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum.

Authors:  H Kilbinger; R Kruel; I Pfeuffer-Friederich; I Wessler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

9.  An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture.

Authors:  J A Peters; H M Malone; J J Lambert
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

10.  Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves.

Authors:  G Engel; M Göthert; E Müller-Schweinitzer; E Schlicker; L Sistonen; P A Stadler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-09       Impact factor: 3.000
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.