Literature DB >> 6578890

An HLA-All association with the hemochromatosis allele?

L Le Mignon, M Simon, R Fauchet, G Edan, M Le Reun, P Brissot, B Genetet, M Bourel.   

Abstract

Two hundred and seventy-four patients with hemochromatosis and 1005 controls were HLA-typed, and HLA haplotypes were determined for 163 patients and 123 controls. The increased frequency of antigen A3 and haplotypes A3, B7 and A3, B14 in patients with hemochromatosis was confirmed. After correction for the space taken up by A3, a significant increase in All was found. This increase could not be explained by cross reaction between A3 and All. All showed a phenotype association and a haplotype link with Bw35. The genetic significance of this increased All frequency is discussed.

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Year:  1983        PMID： 6578890     DOI： 10.1111/j.1399-0004.1983.tb02234.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  7 in total

1.  Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

Authors:  J M Lalouel; L Le Mignon; M Simon; R Fauchet; M Bourel; D C Rao; N E Morton
Journal:  Am J Hum Genet       Date:  1985-07       Impact factor: 11.025

2.  A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association.

Authors:  M Simon; L Le Mignon; R Fauchet; J Yaouanq; V David; G Edan; M Bourel
Journal:  Am J Hum Genet       Date:  1987-08       Impact factor: 11.025

3.  DNA polymorphism related to the idiopathic hemochromatosis gene: evidence in a recombinant family.

Authors:  V David; P Paul; M Simon; J Y Le Gall; R Fauchet; I Gicquel; I Dugast; L Le Mignon; J Yaouanq; D Cohen
Journal:  Hum Genet       Date:  1986-10       Impact factor: 4.132

4.  Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron, and HLA.

Authors:  I B Borecki; G M Lathrop; G E Bonney; J Yaouanq; D C Rao
Journal:  Am J Hum Genet       Date:  1990-09       Impact factor: 11.025

5.  Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE)

Authors:  J Yaouanq; M Perichon; M Chorney; P Pontarotti; A Le Treut; A el Kahloun; V Mauvieux; M Blayau; A M Jouanolle; B Chauvel
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

6.  Idiopathic haemochromatosis and HLA antigens in Italy: is A3 Bw35 HLA haplotype a marker for idiopathic haemochromatosis gene in north east regions?

Authors:  A Piperno; S Fargion; N Panaiotopoulos; E Del Ninno; M T Taddei; G Fiorelli
Journal:  J Clin Pathol       Date:  1986-02       Impact factor: 3.411

7.  Non-HLA-linked hemochromatosis in a Chinese woman.

Authors:  M Oliver; L Scully; C Guiraudon; P C Adams
Journal:  Dig Dis Sci       Date:  1995-07       Impact factor: 3.199
  7 in total

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