Literature DB >> 6577602

Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy.

K J Ibbotson, S M D'Souza, K W Ng, C K Osborne, M Niall, T J Martin, G R Mundy.   

Abstract

Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.

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Year:  1983        PMID： 6577602     DOI： 10.1126/science.6577602

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  35 in total

1.  Hydrolysis of transforming growth factor-alpha by cell-surface peptidases in vitro.

Authors:  Y Choudry; A J Kenny
Journal:  Biochem J       Date:  1991-11-15       Impact factor: 3.857

Review 2.  Incidence and pathophysiology of hypercalcemia.

Authors:  G R Mundy
Journal:  Calcif Tissue Int       Date:  1990       Impact factor: 4.333

3.  Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures.

Authors:  N Takahashi; T Kukita; B R MacDonald; A Bird; G R Mundy; L M McManus; M Miller; A Boyde; S J Jones; G D Roodman
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

4.  Tumor products and the hypercalcemia of malignancy.

Authors:  G R Mundy; K J Ibbotson; S M D'Souza
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

5.  Molecular characterization of the EGF receptor and involvement of glycosyl moieties in the binding of EGF to its receptor on a clonal osteosarcoma cell line, UMR 106-06.

Authors:  J M Moseley; L J Suva
Journal:  Calcif Tissue Int       Date:  1986-02       Impact factor: 4.333

6.  Specific down-regulation of parathyroid hormone (PTH) receptors and responses to PTH by tumour necrosis factor alpha and retinoic acid in UMR 106-06 osteoblast-like osteosarcoma cells.

Authors:  H G Schneider; E H Allan; J M Moseley; T J Martin; D M Findlay
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

7.  Humoral hypercalcemia complicating adenosquamous carcinoma of the proximal colon.

Authors:  C H Berkelhammer; A L Baker; G E Block; D G Bostwick; F Michelassi
Journal:  Dig Dis Sci       Date:  1989-01       Impact factor: 3.199

8.  Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long-bone cultures.

Authors:  J A Lorenzo; J Quinton; S Sousa; L G Raisz
Journal:  J Clin Invest       Date:  1986-06       Impact factor: 14.808

9.  Parathyroid hormone like bioactivity measured by cytochemical bioassay in a patient with malignant bladder disease.

Authors:  S Roche; J F Fielding; N Loveridge
Journal:  Ir J Med Sci       Date:  1988-12       Impact factor: 1.568

Review 10.  Hypercalcaemia of malignancy.

Authors:  P J Kelly; J A Eisman
Journal:  Cancer Metastasis Rev       Date:  1989-06       Impact factor: 9.264
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