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Literature DB >> 6576785

Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord.

K Kangawa, N Minamino, A Fukuda, H Matsuo.

Abstract

A new peptide, designated "neuromedin K" has been discovered and isolated from porcine spinal cord by using bioassays for a tachykinin-like effect on the contractility of smooth muscle preparation from guinea-pig ileum. Porcine neuromedin K has been identified by microsequencing as: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2. The sequence thus determined has been confirmed by synthesis. Neuromedin K has been found to have not only a remarkable sequence homology to kassinin and substance P, but also a prompt stimulant activity on guinea-pig ileum in a manner similar to that of substance P, suggesting that neuromedin K may be involved in neural transmission.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6576785 DOI： 10.1016/0006-291x(83)90813-6

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

40 in total

Review 1. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.

Authors: Martin S Steinhoff; Bengt von Mentzer; Pierangelo Geppetti; Charalabos Pothoulakis; Nigel W Bunnett
Journal: Physiol Rev Date: 2014-01 Impact factor: 37.312

2. In vivo and in vitro actions of mammalian tachykinins.

Authors: U Holzer-Petsche; E Schimek; R Amann; F Lembeck
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-08 Impact factor: 3.000

3. Tachykinins and bombesin excite non-pyramidal neurones in rat hippocampus.

Authors: J J Dreifuss; M Raggenbass
Journal: J Physiol Date: 1986-10 Impact factor: 5.182

4. Bronchoconstrictor and hypotensive effects in relation to pharmacokinetics of tachykinins in the guinea-pig--evidence for extraneuronal cleavage of neuropeptide K to neurokinin A.

Authors: C R Martling; E Theodorsson-Norheim; I Norheim; J M Lundberg
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1987-08 Impact factor: 3.000

Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord.

Review 1. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.

2. In vivo and in vitro actions of mammalian tachykinins.

3. Tachykinins and bombesin excite non-pyramidal neurones in rat hippocampus.

4. Bronchoconstrictor and hypotensive effects in relation to pharmacokinetics of tachykinins in the guinea-pig--evidence for extraneuronal cleavage of neuropeptide K to neurokinin A.

5. Striato-nigral dynorphin and substance P pathways in the rat. II. Functional analysis.

6. Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link.

7. Substance P, neurokinin A and neurokinin B in the ocular response to injury in the rabbit.

8. Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.

9. Effects of interactions of naturally-occurring neuropeptides on blood flow in the rat knee joint.

10. Comparison of cardiovascular and bronchoconstrictor effects of substance P, substance K and other tachykinins.