Literature DB >> 6575779

The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices.

Y Fujimoto, H Tanioka, I Keshi, T Fujita.   

Abstract

Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.

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Year:  1983        PMID： 6575779      PMCID： PMC1152025          DOI： 10.1042/bj2120167

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors.

Authors:  A Danon; M Heimberg; J A Oates
Journal:  Biochim Biophys Acta       Date:  1975-06-23

2.  Lipid peroxidation damage to cell components.

Authors:  A L Tappel
Journal:  Fed Proc       Date:  1973-08

3.  Quantitative and qualitative analyses of isolated lipid droplets from interstitial cells in renal papillae from various species.

Authors:  I Bojesen
Journal:  Lipids       Date:  1974-11       Impact factor: 1.880

4.  A sensitive method for the determination of prostaglandins by gas chromatography with electron-capture detection.

Authors:  G H Jouvenaz; D H Nugteren; R K Beerthuis; D A van Dorp
Journal:  Biochim Biophys Acta       Date:  1970-02-10

5.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

6.  Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde.

Authors:  K S Chio; A L Tappel
Journal:  Biochemistry       Date:  1969-07       Impact factor: 3.162

7.  The importance of phospholipase-A2 in prostaglandin biosynthesis.

Authors:  R J Flower; G J Blackwell
Journal:  Biochem Pharmacol       Date:  1976-02-01       Impact factor: 5.858

8.  Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits.

Authors:  K Comai; S J Farber; J R Paulsrud
Journal:  Lipids       Date:  1975-09       Impact factor: 1.880

9.  Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

Authors:  T Miyamoto; N Ogino; S Yamamoto; O Hayaishi
Journal:  J Biol Chem       Date:  1976-05-10       Impact factor: 5.157

10.  Prostaglandin synthetase system--resolution into oxygenase and isomerase components.

Authors:  T Miyamoto; S Yamamoto; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205
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  5 in total

1.  Stimulation of prostaglandin E2 synthesis by exogenous phospholipase A2 and C in rabbit kidney medulla slices.

Authors:  Y Fujimoto; N Akamatsu; A Hattori; T Fujita
Journal:  Biochem J       Date:  1984-02-15       Impact factor: 3.857

2.  Effect of angiotensin-converting enzyme inhibitor YS980 on prostaglandin synthesis in rabbit kidney medulla slices.

Authors:  Y Fujimoto; K Wada; M Kaneko; T Fujita
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

3.  Uptake of secondary autoxidation products of linoleic acid by the rat.

Authors:  K Kanazawa; E Kanazawa; M Natake
Journal:  Lipids       Date:  1985-07       Impact factor: 1.880

4.  Effect of diarachidonin on prostaglandin E2 synthesis in rabbit kidney medulla slices.

Authors:  Y Fujimoto; H Uno; C Kagen; T Ueno; T Fujita
Journal:  Biochem J       Date:  1985-12-15       Impact factor: 3.857

5.  Protective effect of quinacrine against glycerol-induced acute kidney injury in rats.

Authors:  Abdulrahman K Al Asmari; Khalid Tariq Al Sadoon; Ali Ahmed Obaid; Deivakadatcham Yesunayagam; Mohammad Tariq
Journal:  BMC Nephrol       Date:  2017-01-28       Impact factor: 2.388
  5 in total

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