The effect of a prostaglandin synthetase inhibitor on the hormonal profile and the endometrium in women.

A prostaglandin synthetase inhibitor, naproxen, was given continuously throughout the menstrual cycle at a dose of 250 mg b.i.d. to 10 healthy fertile women. Blood samples were drawn three times a week during an earlier control cycle and during the treatment cycle and analyzed for LH, FSH, prolactin, estradiol and progesterone. Endometrial biopsies were taken in the secretory phase. Naproxen treatment did not suppress ovulation in any of the cycles and did not affect the corpus luteum function. In only one of the endometrial samples taken was the density of the lysosomes increased in the treatment cycle compared with the control cycle.