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Literature DB >> 6572615

Brain Ia antigens have a bone marrow origin.

J P Ting, D F Nixon, L P Weiner, J A Frelinger.

Abstract

Our results, using radiation-induced bone marrow chimeras, demonstrate that the Ia antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of Ia in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

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Year: 1983 PMID： 6572615 DOI： 10.1007/bf00364413

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

20 in total

1. Neurochemical and morphological studies of bulk-isolated rat brain cells. I. A new approach to the preparation of cerebral neurones.

Authors: H H Althaus; W B Huttner; V Neuhoff
Journal: Hoppe Seylers Z Physiol Chem Date: 1977-09

2. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

Authors: V T Oi; P P Jones; J W Goding; L A Herzenberg; L A Herzenberg
Journal: Curr Top Microbiol Immunol Date: 1978 Impact factor: 4.291

3. Detection of Ia antigens on Langerhans cells in guinea pig skin.

Authors: G Stingl; S I Katz; E M Shevach; E Wolff-Schreiner; I Green
Journal: J Immunol Date: 1978-02 Impact factor: 5.422

4. Mouse epidermal Ia molecules have a bone marrow origin.

Authors: J G Frelinger; L Hood; S Hill; J A Frelinger
Journal: Nature Date: 1979-11-15 Impact factor: 49.962

5. The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen-specific T cell proliferation.

Authors: L K Richman; R J Klingenstein; J A Richman; W Strober; J A Berzofsky
Journal: J Immunol Date: 1979-12 Impact factor: 5.422

6. Antigen presentation by guinea pig alveolar macrophages.

Authors: M F Lipscomb; G B Toews; C R Lyons; J W Uhr
Journal: J Immunol Date: 1981-01 Impact factor: 5.422

7. An improved method for isolation of H-2 and Ia alloantigens with immunoprecipitation induced by protein A-bearing staphylococci.

Authors: S E Cullen; B D Schwartz
Journal: J Immunol Date: 1976-07 Impact factor: 5.422

5. Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro.

Authors: W Risau; B Engelhardt; H Wekerle
Journal: J Cell Biol Date: 1990-05 Impact factor: 10.539

Review 6. Cell-mediated immunity in virus infections of the central nervous system.

Authors: P C Doherty
Journal: Ann N Y Acad Sci Date: 1988 Impact factor: 5.691

7. Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.

Authors: J D Sedgwick; S Schwender; R Gregersen; R Dörries; V ter Meulen
Journal: J Exp Med Date: 1993-04-01 Impact factor: 14.307

7 in total

Brain Ia antigens have a bone marrow origin.

1. Neurochemical and morphological studies of bulk-isolated rat brain cells. I. A new approach to the preparation of cerebral neurones.

2. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

3. Detection of Ia antigens on Langerhans cells in guinea pig skin.

4. Mouse epidermal Ia molecules have a bone marrow origin.

5. The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen-specific T cell proliferation.

6. Antigen presentation by guinea pig alveolar macrophages.

7. An improved method for isolation of H-2 and Ia alloantigens with immunoprecipitation induced by protein A-bearing staphylococci.

8. Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation.

9. Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture.

10. The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state.

1. Bone marrow transplantation in canine mucopolysaccharidosis I. Effects within the central nervous system.

2. Effects of phenytoin on cell-mediated immunity.

Review 3. Production, regulation and role of nitric oxide in glial cells.

4. Astrocytes produce interferon that enhances the expression of H-2 antigens on a subpopulation of brain cells.

5. Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro.

Review 6. Cell-mediated immunity in virus infections of the central nervous system.

7. Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.