Literature DB >> 6571996

Developmental regulation of mRNA in mouse heart.

A J Ouellette, D E Croall, J Van Ness, J S Ingwall.   

Abstract

The myocardium contains abundant translatable mRNAs that change during development. Maximal cell-free synthesis of [3H]leucine-, [35S]methionine-, and [35S]cysteine-labeled translation products directed by poly(A)-containing mRNAs from 12-, 14-, and 17-day fetal; 5-day-old neonatal; and 30-day-old adult mouse heart was determined by using one- and two-dimensional polyacrylamide gels. Three general developmental patterns of heart-specific mRNA translation products were observed: two translatable mRNAs were most abundant in 12-day fetal heart; five mRNAs were most abundant in 14- and 17-day fetal heart and occurred only at low concentrations in 12-day fetal and adult heart; four mRNAs, including mRNAs coding for actin, tropomyosin, and myosin light chains 1 and 2, were most abundant in the adult heart. Thus, differentiating cardiac muscle is characterized by a complex pattern of mRNA regulation.

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Year:  1983        PMID： 6571996      PMCID： PMC393344          DOI： 10.1073/pnas.80.1.223

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.

Authors:  R A Laskey; A D Mills
Journal:  Eur J Biochem       Date:  1975-08-15

2.  Protein synthesis and actin heterogeneity in calf muscle cells in culture.

Authors:  R G Whalen; G S Butler-Browne; F Gros
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

3.  The development of mitochondrial oxidative enzymes in rat heart muscle.

Authors:  S A Zeit-Har; Z Drahota
Journal:  Physiol Bohemoslov       Date:  1975

4.  High resolution two-dimensional electrophoresis of proteins.

Authors:  P H O'Farrell
Journal:  J Biol Chem       Date:  1975-05-25       Impact factor: 5.157

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Metallothionein mRNA expression in fetal mouse organs.

Authors:  A J Ouellette
Journal:  Dev Biol       Date:  1982-07       Impact factor: 3.582

7.  An efficient mRNA-dependent translation system from reticulocyte lysates.

Authors:  H R Pelham; R J Jackson
Journal:  Eur J Biochem       Date:  1976-08-01

8.  Molecular characterization of two myosin heavy chain genes expressed in the adult heart.

Authors:  V Mahdavi; M Periasamy; B Nadal-Ginard
Journal:  Nature       Date:  1982-06-24       Impact factor: 49.962

9.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

10.  Messenger RNA for myosin polypeptides: isolation from single myogenic cell cultures.

Authors:  R C Strohman; P S Moss; J Micou-Eastwood; D Spector; A Przybyla; B Paterson
Journal:  Cell       Date:  1977-02       Impact factor: 41.582
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  2 in total

1.  Cardiac mRNA levels during the development and growth of the rat.

Authors:  P M Garber; V A Mezl
Journal:  Basic Res Cardiol       Date:  1988 Jul-Aug       Impact factor: 17.165

2.  Regulation of troponin C synthesis in primary culture of chicken cardiac muscle cells.

Authors:  S B Malhotra; J Bag
Journal:  Mol Biol Rep       Date:  1987       Impact factor: 2.316
  2 in total

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