Literature DB >> 6571226

Heterogeneity of 5-hydroxytryptamine receptors in the rat uterus and stomach strip.

S J Wrigglesworth.   

Abstract

Experiments were performed using the rat isolated uterus and the rat stomach strip to investigate the effects of 5-hydroxytryptamine (5-HT) on 5-HT receptors in the presence of different antagonists. Amitriptyline, methysergide and trazodone were used to antagonize the response to 5-HT in these tissues. The pA2 value for amitriptyline with 5-HT as the agonist was estimated from the Schild plot analysis and found to differ significantly (P less than 0.05) in the stomach strip (6.36) from that in the isolated uterus (9.06). A similar difference was found using trazodone; here the pA2 value was 6.74 in the stomach strip and 8.49 in the isolated uterus. These results indicate a difference between the two tissues. This difference is discussed in terms of heterogeneity of 5-HT receptors.

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Year:  1983        PMID： 6571226      PMCID： PMC2045060          DOI： 10.1111/j.1476-5381.1983.tb10059.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  19 in total

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5.  Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues.

Authors:  R A Glennon; S M Liebowitz; E C Mack
Journal:  J Med Chem       Date:  1978-08       Impact factor: 7.446

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Authors:  A L Frankhuijzen; I L Bonta
Journal:  Eur J Pharmacol       Date:  1974-05       Impact factor: 4.432

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8.  Effect of mianserin, a potent anti-serotonin agent, on the isolated rat stomach fundus preparation.

Authors:  A L Frankhuyzen; I L Bonta
Journal:  Eur J Pharmacol       Date:  1974-01       Impact factor: 4.432

9.  Evidence for two types of excitatory receptor for 5-hydroxytryptamine in dog isolated vasculature.

Authors:  E Apperley; W Feniuk; P P Humphrey; G P Levy
Journal:  Br J Pharmacol       Date:  1980-02       Impact factor: 8.739

10.  Serotonin. I. receptors involved in its action.

Authors:  J Offermeier; E J Ariëns
Journal:  Arch Int Pharmacodyn Ther       Date:  1966-11
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  2 in total

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Journal:  J Physiol       Date:  2007-03-29       Impact factor: 5.182

2.  Peripheral 5-HT2-like receptors. Can they be classified with the available antagonists?

Authors:  P Leff; G R Martin
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739
  2 in total

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