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Literature DB >> 656993

Comparison of two benzodiazepines for anaesthesia induction: midazolam and diazepam.

Abstract

Ro 21-3981 is a newly synthesized water soluble benzodiazepine derivative. Its pharmacological properties are similar to diazepam. This investigation was designed to establish the effective induction dosage of Ro 21-3981 and to compare it with diazepam for induction of anaesthesia. The ED50 for Ro 21-3981 induction is 0.15 mg/kg and ED 100 is 0.2 mg/kg. Ro 21-3981 is one and one-half times as potent as diazepam (0.3 mg/kg) and more rapid in action. There is significantly less pain on injection with Ro 21-3981 as compared to diazepam. Cardiovascular stability and apnoea were observed with both drugs. Ro 21-3981 is a promising anaesthetic induction drug that merits further human study.

Entities: Chemical Disease Species

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Year: 1978 PMID： 656993 DOI： 10.1007/BF03004881

Source DB: PubMed Journal: Can Anaesth Soc J ISSN： 0008-2856

9 in total

1. PREANESTHESIA MEDICATION: DOUBLE-BLIND STUDY OF A NEW DRUG, DIAZEPAM.

Authors: A L BRANDT; F D OAKES
Journal: Anesth Analg Date: 1965 Jan-Feb Impact factor: 5.108

2. Systemic and coronary hemodynamic effects of diazepam in patients with normal and diseased coronary arteries.

Authors: P Côté; P Guéret; M G Bourassa
Journal: Circulation Date: 1974-12 Impact factor: 29.690

3. Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.

Authors: L Hillestad; T Hansen; H Melsom; A Drivenes
Journal: Clin Pharmacol Ther Date: 1974-09 Impact factor: 6.875

4. Effect of diazepam on myocardial blood flow of patients with and without coronary artery disease.

Authors: H Ikram; A P Rubin; R F Jewkes
Journal: Br Heart J Date: 1973-06

5. Memory under diazepam-morphine neuroleptanesthesia in male surgical patients.

Authors: L Eisenberg; H A Taub; A Burana
Journal: Anesth Analg Date: 1974 Jul-Aug Impact factor: 5.108

Review 6. The benzodiazepines. A review of their actions and uses relative to anaesthetic practice.

Authors: J W Dundee; W H Haslett
Journal: Br J Anaesth Date: 1970-03 Impact factor: 9.166

7. Cardiopulmonary effects of diazepam.

Authors: S Rao; R W Sherbaniuk; K Prasad; S J Lee; B J Sproule
Journal: Clin Pharmacol Ther Date: 1973 Mar-Apr Impact factor: 6.875

8. The effects of diazepam on respiration in patients with obstructive pulmonary disease.

Authors: R F Catchlove; E R Kafer
Journal: Anesthesiology Date: 1971-01 Impact factor: 7.892

9. A study of diazepam (Valium) for induction of anaesthesia.

Authors: G M Wyant; L J Studney
Journal: Can Anaesth Soc J Date: 1970-03

9 in total

24 in total

1. Intravenous midazolam: a study of the degree of oxygen desaturation occurring during upper gastrointestinal endoscopy.

Authors: G D Bell; P A Reeve; M Moshiri; A Morden; T Coady; P J Stapleton; R F Logan
Journal: Br J Clin Pharmacol Date: 1987-06 Impact factor: 4.335

Comparison of two benzodiazepines for anaesthesia induction: midazolam and diazepam.

1. PREANESTHESIA MEDICATION: DOUBLE-BLIND STUDY OF A NEW DRUG, DIAZEPAM.

2. Systemic and coronary hemodynamic effects of diazepam in patients with normal and diseased coronary arteries.

3. Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.

4. Effect of diazepam on myocardial blood flow of patients with and without coronary artery disease.

5. Memory under diazepam-morphine neuroleptanesthesia in male surgical patients.

Review 6. The benzodiazepines. A review of their actions and uses relative to anaesthetic practice.

7. Cardiopulmonary effects of diazepam.

8. The effects of diazepam on respiration in patients with obstructive pulmonary disease.

9. A study of diazepam (Valium) for induction of anaesthesia.

1. Intravenous midazolam: a study of the degree of oxygen desaturation occurring during upper gastrointestinal endoscopy.

2. CSF penetration and pharmacokinetics of midazolam.

3. Chronopharmacokinetic study with prolonged infusion of midazolam.

4. Influence of serum protein, serum albumin concentrations and dose on midazolam anaesthesia induction times.

5. Midazolam maleate induction in patients with ischaemic heart disease: haemodynamic observations.

6. The pharmacokinetics of midazolam in man.

7. Comparison of thiopentone and midazolam for induction of anaesthesia: influence of diazepam premedication.

8. Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in ill surgical patients.

9. COMPARISON OF MIDAZOLAM AND THIOPENTONE AS INDUCTION AGENTS IN GENERAL ANAESTHESIA.

Review 10. New intravenous anaesthetics and neuromuscular blocking drugs. A review of their properties and clinical use.