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Literature DB >> 656820

Anticonvulsants and thyroid function.

P P Yeo, D Bates, J G Howe, W A Ratcliffe, C W Schardt, A Heath, D C Evered.

Abstract

Serum total and free thyroid hormone concentrations were estimated in 42 patients with epilepsy taking anticonvulsants (phenytoin, phenobarbitone, and carbamazepine either singly or in combination). There was a significant reduction in total thyroxine (TT4), free thyroxine (FT4), and free triiodothyronine (FT3) in the treated group compared with controls. Free hormone concentrations were lower than total hormone concentrations, suggesting that increased clearance of thyroid hormones occurs in patients receiving anticonvulsants. Detailed analysis indicated that phenytoin had a significant depressant effect on TT4, FT4, FT3, and reverse T3 (rT3). Phenobarbitone and carbamazepine had no significant main effects, but there were significant interactions between phenytoin and carbamazepine for TT4 and FT4. phenobarbitone and carbamazepine for FT3, and phenytoin and phenobarbitone for rT3.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1978 PMID： 656820 PMCID： PMC1605396 DOI： 10.1136/bmj.1.6127.1581

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

16 in total

1. The radioimmunoassay of 3,3',5' - triiodothyronine (reverse T3) in unextracted human serum.

Authors: W A Ratcliffe; J Marshall; J G Ratcliffe
Journal: Clin Endocrinol (Oxf) Date: 1976-11 Impact factor: 3.478

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Authors: D C Evered; P A Vice; E Green; D Appleton
Journal: J Clin Pathol Date: 1976-12 Impact factor: 3.411

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Authors: D M Mendoza; E V Flock; C A Owen; J Paris
Journal: Endocrinology Date: 1966-07 Impact factor: 4.736

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Authors: H Gharib; J M Munoz
Journal: Metabolism Date: 1974-06 Impact factor: 8.694

5. Radioimmunoassay of triiodothyronine in unextracted human serum.

Authors: R D Hesch; D Evered
Journal: Br Med J Date: 1973-03-17

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Authors: R W Lightfoot; C L Christian
Journal: J Clin Endocrinol Metab Date: 1966-03 Impact factor: 5.958

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Authors: K Liewendahl; H Majuri
Journal: Scand J Clin Lab Invest Date: 1976-03 Impact factor: 1.713

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Authors: J H Oppenheimer; G Bernstein; M I Surks
Journal: J Clin Invest Date: 1968-06 Impact factor: 14.808

9. Radioimmunoassay of free thyroid hormone concentrations in the investigation of thyroid disease.

Authors: P P Yeo; M Lewis; D C Evered
Journal: Clin Endocrinol (Oxf) Date: 1977-02 Impact factor: 3.478

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Authors: J H OPPENHEIMER; R R TAVERNETTI
Journal: Endocrinology Date: 1962-09 Impact factor: 4.736

11 in total

1. Nuclear receptors CAR and PXR in the regulation of hepatic metabolism.

Authors: E S Tien; M Negishi
Journal: Xenobiotica Date: 2006 Oct-Nov Impact factor: 1.908

Review 2. Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction.

Authors: M Strolin Benedetti; R Whomsley; E Baltes; F Tonner
Journal: Eur J Clin Pharmacol Date: 2005-11-24 Impact factor: 2.953

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Authors: F De Luca; T Arrigo; E Pandullo; M F Siracusano; S Benvenga; F Trimarchi
Journal: Eur J Pediatr Date: 1986-04 Impact factor: 3.183

4. Endocrine function changes in young males during long-term antiepileptic therapy with phenobarbitone and carbamazepine.

Authors: L Rozza; A Marcolla; G Ferrari
Journal: Ital J Neurol Sci Date: 1987-08

10. The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.

Authors: A A Connacher; D Q Borsey; M C Browning; D L Davidson; R T Jung
Journal: Postgrad Med J Date: 1987-10 Impact factor: 2.401