Literature DB >> 6568150

Which motor disorder in Parkinson's disease indicates the true motor function of the basal ganglia?

C D Marsden.   

Abstract

Parkinson's disease in its earlier stages is argued to be the best available model for human basal ganglia dysfunction. The negative motor symptoms of Parkinson's disease are considered to give the greatest clue to normal function of this region of the brain. Particular attention is given to disorders of movement. These include delayed initiation and slowed execution of simple fast movements, due to abnormal specification of initial agonist activity. This might compromise predictive motor action, but this is shown to be preserved in Parkinson's disease. Disorders of more complex movements, such as repetitive, concurrent and sequential motor actions, are also abnormal in Parkinson's disease. These various defects are discussed in terms of a motor strategy involving the selection and sequencing of motor programmes to form a motor plan, and the initiation and execution of that motor plan. On the evidence available, it is suggested that patients with Parkinson's disease are unable to automatically execute learnt motor plans.

Entities:  

Mesh:

Year:  1984        PMID: 6568150     DOI: 10.1002/9780470720882.ch12

Source DB:  PubMed          Journal:  Ciba Found Symp        ISSN: 0300-5208


  13 in total

1.  Coding of serial order by neostriatal neurons: a "natural action" approach to movement sequence.

Authors:  J W Aldridge; K C Berridge
Journal:  J Neurosci       Date:  1998-04-01       Impact factor: 6.167

2.  Implementation of action sequences by a neostriatal site: a lesion mapping study of grooming syntax.

Authors:  H C Cromwell; K C Berridge
Journal:  J Neurosci       Date:  1996-05-15       Impact factor: 6.167

3.  Impact of regional striatal dopaminergic function on kinematic parameters of Parkinson's disease.

Authors:  Myung Jun Lee; Sha-Lom Kim; Chul Hyoung Lyoo; J O Rinne; Myung-Sik Lee
Journal:  J Neural Transm (Vienna)       Date:  2014-08-22       Impact factor: 3.575

4.  Differential effect of Huntington's and Parkinson's diseases in programming motor sequences of varied lengths.

Authors:  L Yágüez; H W Lange; V Hömberg
Journal:  J Neurol       Date:  2005-07-27       Impact factor: 4.849

5.  Planning and spatial working memory in Parkinson's disease.

Authors:  R G Morris; J J Downes; B J Sahakian; J L Evenden; A Heald; T W Robbins
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-06       Impact factor: 10.154

6.  Progressive bradykinesia and hypokinesia of ocular pursuit in Parkinson's disease.

Authors:  G U Lekwuwa; G R Barnes; C J Collins; P Limousin
Journal:  J Neurol Neurosurg Psychiatry       Date:  1999-06       Impact factor: 10.154

Review 7.  Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.

Authors:  Holly R Robertson; Guoping Feng
Journal:  J Child Psychol Psychiatry       Date:  2011-02-10       Impact factor: 8.982

8.  Abnormal force patterns for multidirectional postural responses in patients with Parkinson's disease.

Authors:  Diana Dimitrova; John Nutt; Fay B Horak
Journal:  Exp Brain Res       Date:  2004-02-27       Impact factor: 1.972

Review 9.  A "good parent" function of dopamine: transient modulation of learning and performance during early stages of training.

Authors:  Jon C Horvitz; Won Yung Choi; Cecile Morvan; Yaniv Eyny; Peter D Balsam
Journal:  Ann N Y Acad Sci       Date:  2007-03-14       Impact factor: 5.691

10.  The relationship between articulatory control and improved phonemic accuracy in childhood apraxia of speech: a longitudinal case study.

Authors:  Maria I Grigos; Nicole Kolenda
Journal:  Clin Linguist Phon       Date:  2010-01       Impact factor: 1.346

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