Chlorpromazine and serial reaction performance.

The effect of 25 mg or 75 mg of chlorpromazine on the serial reaction performance of 12 male human subjects was studied. Speed or number of correct responses was reduced by the high dose of chlorpromazine and errors of commission and omission were increased. The adverse effect of the drug upon speed appeared only at the end of the half-hour test. By contrast the adverse effect upon gaps and errors was apparent throughout the test and there was no interaction with test duration.