Literature DB >> 6565489

Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.

J S Bartholomew, D A Lowther, C J Handley.   

Abstract

Treatment of bovine articular cartilage in culture with a low molecular weight elastase purified from rabbit polymorphonuclear leukocytes resulted in degradation and release of proteoglycans from the tissue, coupled with a prolonged inhibition of proteoglycan biosynthesis. These observations are consistent with those seen in experimental arthritis induced in rabbits. Comparison of the size of the proteoglycan degradation products extracted from elastase-treated cartilage in culture with that from arthritic cartilage showed marked similarities. The results strongly suggest that leukocyte elastase is a contributing factor in proteoglycan degradation and inhibition of synthesis in inflammatory joint disease.

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Year:  1984        PMID： 6565489     DOI： 10.1002/art.1780270810

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  9 in total

1.  Neutrophil-mediated cartilage injury in vitro is enhanced by tumour necrosis factor alpha.

Authors:  I C Kowanko; E J Bates; A Ferrante
Journal:  Rheumatol Int       Date:  1990       Impact factor: 2.631

2.  Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines.

Authors:  G A Homandberg; F Hui; C Wen; C Purple; K Bewsey; H Koepp; K Huch; A Harris
Journal:  Biochem J       Date:  1997-02-01       Impact factor: 3.857

3.  Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study.

Authors:  W B van den Berg; F A van de Loo; W A Zwarts; I G Otterness
Journal:  Ann Rheum Dis       Date:  1988-10       Impact factor: 19.103

4.  Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of human neutrophils to damage human articular cartilage.

Authors:  E J Bates; I C Kowanko; A Ferrante
Journal:  Ann Rheum Dis       Date:  1988-01       Impact factor: 19.103

5.  The effects of trypsin treatment on proteoglycan biosynthesis by bovine articular cartilage.

Authors:  J S Bartholomew; C J Handley; D A Lowther
Journal:  Biochem J       Date:  1985-04-15       Impact factor: 3.857

6.  Elastase secreted by activated polymorphonuclear leucocytes causes chondrocyte damage and matrix degradation in intact articular cartilage: escape from inactivation by alpha-1-proteinase inhibitor.

Authors:  J Schalkwijk; W B van den Berg; L B van de Putte; L A Joosten
Journal:  Br J Exp Pathol       Date:  1987-02

7.  Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis.

Authors:  S Byers; C J Handley; D A Lowther; A Sriratana
Journal:  Ann Rheum Dis       Date:  1985-07       Impact factor: 19.103

8.  Experimental arthritis in C57black/6 normal and beige (Chediak-Higashi) mice: in vivo and in vitro observations on cartilage degradation.

Authors:  J Schalkwijk; L A Joosten; W B van den Berg; L B van de Putte
Journal:  Ann Rheum Dis       Date:  1988-11       Impact factor: 19.103

9.  Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases.

Authors:  K Kleesiek; R Reinards; D Brackertz; S Neumann; H Lang; H Greiling
Journal:  Rheumatol Int       Date:  1986       Impact factor: 2.631
  9 in total

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