Literature DB >> 656357

An increased effect of pilocarpine on the pupil by application of the drug in oil.

S A Smith, S E Smith, R Lazare.   

Abstract

In healthy volunteers pilocarpine in an oily solution had a greater degree and duration of effect on the pupil than the same amount of drug given in aqueous solution. Blue- and brown-eyed subjects had similar degrees of miosis, but the time taken to reach peak effects was longer with the latter. It can be concluded that eye drops made with an oily solvent may provide an improvement in the treatment of glaucoma with pilocarpine.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 656357      PMCID： PMC1043219          DOI： 10.1136/bjo.62.5.314

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  11 in total

1.  A comparative study of mydriatic and cycloplegic agents; in human subjects without eye disease.

Authors:  R F BARBEE; W O SMITH
Journal:  Am J Ophthalmol       Date:  1957-11       Impact factor: 5.258

2.  Electronic pupillography; a new instrument and some clinical applications.

Authors:  O LOWENSTEIN; I E LOEWENFELD
Journal:  AMA Arch Ophthalmol       Date:  1958-03

3.  Drop size and initial dosing frequency problems of topically applied ophthalmic drugs.

Authors:  S S Chrai; M C Makoid; S P Eriksen; J R Robinson
Journal:  J Pharm Sci       Date:  1974-03       Impact factor: 3.534

4.  [Effect of different concentrations and vehicles on pilocarpine miosis. II. Different vehicles].

Authors:  H Borgmann; W Wurster
Journal:  Klin Monbl Augenheilkd       Date:  1973-07       Impact factor: 0.700

5.  Effect of ocular pigmentation on hypotensive response to pilocarpine.

Authors:  L S Harris; M A Galin
Journal:  Am J Ophthalmol       Date:  1971-11       Impact factor: 5.258

6.  Factors influencing patient noncompliance: a theoretical approach.

Authors:  P Vincent
Journal:  Nurs Res       Date:  1971 Nov-Dec       Impact factor: 2.381

7.  Response to mydriatics in the African.

Authors:  V P Emiru
Journal:  Br J Ophthalmol       Date:  1971-08       Impact factor: 4.638

8.  Role of the vehicle in local treatment of the eye.

Authors:  M S Norn
Journal:  Acta Ophthalmol (Copenh)       Date:  1964

9.  Iris pigmentation and atropine mydriasis.

Authors:  M Salazar; K Shimada; P N Patil
Journal:  J Pharmacol Exp Ther       Date:  1976-04       Impact factor: 4.030

10.  Effects of drug vehicles on ocular contact time.

Authors:  R Hardberger; C Hanna; C M Boyd
Journal:  Arch Ophthalmol       Date:  1975-01
View more
  10 in total

1.  A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.

Authors:  M R al-Sereiti; R L Coakes; D P O'Sullivan; P Turner
Journal:  Br J Clin Pharmacol       Date:  1989-10       Impact factor: 4.335

2.  Relative bioavailability of pilocarpine from a novel ophthalmic delivery system and conventional eyedrop formulations.

Authors:  J A Kelly; P D Molyneux; S A Smith; S E Smith
Journal:  Br J Ophthalmol       Date:  1989-05       Impact factor: 4.638

3.  Comparison of the pupillary, refractive, and hypotensive effects of Ocusert-40 and pilocarpine eyedrops in the treatment of chronic simple glaucoma.

Authors:  S E Smith; S A Smith; A I Friedmann; J M Chaston
Journal:  Br J Ophthalmol       Date:  1979-04       Impact factor: 4.638

4.  Management of acute closed-angle glaucoma with miotics and timolol.

Authors:  P J Airaksinen; K M Saari; T J Tiainen; E A Jaanio
Journal:  Br J Ophthalmol       Date:  1979-12       Impact factor: 4.638

5.  A pharmacological method for measuring the penetration of topical mydriatic drugs in man.

Authors:  F Nicholson; K L Clark; S J Brecker; S A Smith
Journal:  Br J Clin Pharmacol       Date:  1982-09       Impact factor: 4.335

6.  Evidence for a neuropathic aetiology in the small pupil of diabetes mellitus.

Authors:  S A Smith; S E Smith
Journal:  Br J Ophthalmol       Date:  1983-02       Impact factor: 4.638

7.  Eyedrop instillation for reluctant children.

Authors:  S E Smith
Journal:  Br J Ophthalmol       Date:  1991-08       Impact factor: 4.638

8.  Prolonged pulse-entry of pilocarpine with a soluble drug insert.

Authors:  L Salminen; A Urtti; H Kujari; M Juslin
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1983       Impact factor: 3.117

9.  Subsensitivity to cholinoceptor stimulation of the human iris sphincter in situ following acute and chronic administration of cholinomimetic miotic drugs.

Authors:  S A Smith; S E Smith
Journal:  Br J Pharmacol       Date:  1980-07       Impact factor: 8.739

Review 10.  Standards in Pupillography.

Authors:  Carina Kelbsch; Torsten Strasser; Yanjun Chen; Beatrix Feigl; Paul D Gamlin; Randy Kardon; Tobias Peters; Kathryn A Roecklein; Stuart R Steinhauer; Elemer Szabadi; Andrew J Zele; Helmut Wilhelm; Barbara J Wilhelm
Journal:  Front Neurol       Date:  2019-02-22       Impact factor: 4.003
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.