Literature DB >> 6562018

Acyl-kallikrein; a delivery system for the kinin-liberating enzyme.

F Markwardt, J Stürzebecher, H Müller.   

Abstract

Glandular kallikrein can be temporarily acylated at the active centre by 4-amidinophenyl benzoates. The time course of reactivation depends on the nature of the acyl group introduced. Benzoyl kallikrein was used as a delivery system for kallikrein in vivo. In rabbits, bolus injection of the acylated enzyme caused a long-lasting drop in blood pressure due to sustained kinin liberation.

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Year:  1984        PMID: 6562018     DOI: 10.1007/bf01952559

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  8 in total

1.  "Inverse substrates" for trypsin. Efficient enzymatic hydrolysis of certain esters with a cationic center in the leaving group1.

Authors:  K Tanizawa; Y Kasaba; Y Kanaoka
Journal:  J Am Chem Soc       Date:  1977-06-22       Impact factor: 15.419

2.  Kallikrein inhibitors.

Authors:  H Fritz; E Fink; E Truscheit
Journal:  Fed Proc       Date:  1979-12

3.  Synthetic low molecular weight inhibitors of serum kallikrein.

Authors:  F Markwardt; J Drawert; P Walsmann
Journal:  Biochem Pharmacol       Date:  1974-08-15       Impact factor: 5.858

4.  Inhibition of trypsin and thrombin by amidinophenyl esters of aromatic carboxylic acids.

Authors:  F Markwardt; G Wagner; P Walsmann; H Horn; J Stürzebecher
Journal:  Acta Biol Med Ger       Date:  1972

5.  Pharmacological content of hyperproteolytic states in blood by synthetic inhibitors of serine proteinases.

Authors:  F Markwardt
Journal:  Haemostasis       Date:  1978

6.  [Synthesis of antiproteolytic efficent arylcarbonyl-aralkylcarbonyl- and arylsulfonic acid esters of amidinophenols].

Authors:  G Wagner; H Horn
Journal:  Pharmazie       Date:  1973-07       Impact factor: 1.267

7.  Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy.

Authors:  R A Smith; R J Dupe; P D English; J Green
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

8.  Behavior of trypsin and related enzymes toward amidinophenyl esters.

Authors:  M Nozawa; K Tanizawa; Y Kanaoka; H Moriya
Journal:  J Pharmacobiodyn       Date:  1981-08
  8 in total

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