Literature DB >> 6562017

Specific inhibition of human leukocyte elastase by substituted alpha-pyrones.

W C Groutas, W R Abrams, R T Carroll, M K Moi, K E Miller, M T Margolis.   

Abstract

Several a-pyrones have been synthesized and investigated for their in vitro inhibitory activity using a-chymotrypsin (a-CT), porcine pancreatic elastase (PPE) and human leukocyte elastase (HLE). 4-Hydroxy-6-undecyl-2H-pyran-2-one 4, 4-Hydroxy-6-[(1-butyl)heptyl]-2H-pyran-2-one 5 and 4-Methoxy-6-[(1-butyl) heptyl]-2H-pyran-2-one 6 were found to be specific inhibitors of HLE. These compounds constitute a promising new class of HLE inhibitors.

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Year:  1984        PMID： 6562017     DOI： 10.1007/bf01952552

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

Review 1.  Elastase, collagenase, emphysema, and alpha1-antitrypsin deficiency.

Authors:  J Lieberman
Journal:  Chest       Date:  1976-07       Impact factor: 9.410

2.  The induction of emphysema with elastase. I. The evolution of the lesion and the influence of serum.

Authors:  P D Kaplan; C Kuhn; J A Pierce
Journal:  J Lab Clin Med       Date:  1973-09

3.  The purification of human serum 1 -antitrypsin by affinity chromatography on concanavalin A.

Authors:  I E Liener; O R Garrison; Z Pravda
Journal:  Biochem Biophys Res Commun       Date:  1973-03-17       Impact factor: 3.575

4.  Specific inhibition of human granulocyte elastase by cis-unsaturated fatty acids and activation by the corresponding alcohols.

Authors:  B M Ashe; M Zimmerman
Journal:  Biochem Biophys Res Commun       Date:  1977-03-07       Impact factor: 3.575

5.  Elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces.

Authors:  S Omura; H Ohno; T Saheki; M Yoshida; A Nakagawa
Journal:  Biochem Biophys Res Commun       Date:  1978-07-28       Impact factor: 3.575

6.  Inhibition of human leucocyte elastase activity by cigarette smoke.

Authors:  A Ejiofor; D C Hutchison; H Baum
Journal:  Biosci Rep       Date:  1981-09       Impact factor: 3.840

7.  Mechanism-based inhibitors of elastase.

Authors:  W C Groutas; R C Badger; T D Ocain; D Felker; J Frankson; M Theodorakis
Journal:  Biochem Biophys Res Commun       Date:  1980-08-29       Impact factor: 3.575

8.  Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin).

Authors:  B McRae; K Nakajima; J Travis; J C Powers
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162
  8 in total
  2 in total

1.  Elasnin Effectively Eradicates Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Biofilms.

Authors:  Jordy Evan Sulaiman; Lexin Long; Pei-Yuan Qian; Henry Lam
Journal:  Microbiol Spectr       Date:  2022-02-23

Review 2.  Potentials of Musa Species Fruits against Oxidative Stress-Induced and Diet-Linked Chronic Diseases: In Vitro and In Vivo Implications of Micronutritional Factors and Dietary Secondary Metabolite Compounds.

Authors:  Barnabas Oluwatomide Oyeyinka; Anthony Jide Afolayan
Journal:  Molecules       Date:  2020-10-30       Impact factor: 4.411
  2 in total

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