Literature DB >> 6561228

Elastase as a marker for neutrophilic myeloid cells.

J A Kramps, P van der Valk, M M van der Sandt, J Lindeman, C J Meijer.   

Abstract

The immunohistochemical results obtained with antibodies directed against human neutrophil elastase is described. It was found that neutrophil elastase can be used as a specific marker of cells of the neutrophilic lineage. In normal hematopoietic cell preparations, only promyelocytes and more differentiated myeloid cells stain positive for elastase. In acute or chronic myeloid and myelomonocytic leukemia, the same neutrophil myeloid cells stain positive, whereas neoplastic cells of the monocytoid line are negative. Using elastase in conjunction with other markers, it is possible to differentiate easily the involvement of different cell lines in myeloproliferative diseases.

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Year:  1984        PMID： 6561228     DOI： 10.1177/32.4.6561228

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  9 in total

1.  Antibacterial activity of antileukoprotease.

Authors:  P S Hiemstra; R J Maassen; J Stolk; R Heinzel-Wieland; G J Steffens; J H Dijkman
Journal:  Infect Immun       Date:  1996-11       Impact factor: 3.441

2.  Detection of extracellular neutrophil elastase in hamster lungs after intratracheal instillation of E. coli lipopolysaccharide using a fluorogenic, elastase-specific, synthetic substrate.

Authors:  A Rudolphus; J Stolk; C van Twisk; C J van Noorden; J H Dijkman; J A Kramps
Journal:  Am J Pathol       Date:  1992-07       Impact factor: 4.307

3.  High expression of neutrophil elastase predicts improved survival in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Authors:  Chelsea J Gudgeon; Kimberly H Harrington; George S Laszlo; Todd A Alonzo; Robert B Gerbing; Alan S Gamis; Susana C Raimondi; Betsy A Hirsch; Soheil Meshinchi; Roland B Walter
Journal:  Leuk Lymphoma       Date:  2012-07-09

4.  Use of monoclonal antibody against human neutrophil elastase in normal and leukaemic myeloid cells.

Authors:  K A Pulford; W N Erber; J A Crick; I Olsson; K J Micklem; K C Gatter; D Y Mason
Journal:  J Clin Pathol       Date:  1988-08       Impact factor: 3.411

5.  Colocalization of elastase and myeloperoxidase in human blood and bone marrow neutrophils using a monoclonal antibody and immunogold.

Authors:  E M Cramer; J E Beesley; K A Pulford; J Breton-Gorius; D Y Mason
Journal:  Am J Pathol       Date:  1989-06       Impact factor: 4.307

6.  Identification of Key Genes Associated with Changes in the Host Response to Severe Burn Shock: A Bioinformatics Analysis with Data from the Gene Expression Omnibus (GEO) Database.

Authors:  Xiao Fang; Shu-Fang Duan; Yu-Zhou Gong; Fei Wang; Xu-Lin Chen
Journal:  J Inflamm Res       Date:  2020-12-01

7.  Characterization of Ex Vivo and In Vitro Wnt Transcriptome Induced by Spinal Cord Injury in Rat Microglial Cells.

Authors:  Carlos González-Fernández; Pau González; Francisco González-Pérez; Francisco Javier Rodríguez
Journal:  Brain Sci       Date:  2022-05-30

8.  Expression of the neutrophil elastase gene during human bone marrow cell differentiation.

Authors:  P Fouret; R M du Bois; J F Bernaudin; H Takahashi; V J Ferrans; R G Crystal
Journal:  J Exp Med       Date:  1989-03-01       Impact factor: 14.307

9.  Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.

Authors:  WonJae Lee; Song Yi Ko; Muhaned S Mohamed; Hilary A Kenny; Ernst Lengyel; Honami Naora
Journal:  J Exp Med       Date:  2018-12-19       Impact factor: 14.307
  9 in total

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