Literature DB >> 655925

Alteration of the blood-retinal barrier in experimental diabetes mellitus.

S Waltman, T Krupin, S Hanish, C Oestrich, B Becker.   

Abstract

Vitreous fluorophotometry was used to evaluate the integrity of the blood-retinal barrier to fluorescein in hooded rats. Streptozotocin-induced diabetes mellitus caused a breakdown of this barrier within ten days. Normalization of blood glucose levels with insulin significantly reduced (P less than .005) the increased permeability. This functional microangiopathy might prove to be the earliest detectable change in the retinal circulation in experimental diabetes.

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Year:  1978        PMID： 655925     DOI： 10.1001/archopht.1978.03910050480018

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN： 0003-9950


  12 in total

1.  Immunohistochemical localization of blood-retinal barrier breakdown in human diabetics.

Authors:  S A Vinores; C Gadegbeku; P A Campochiaro; W R Green
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

2.  Influence of metabolic control on the blood-retinal barrier in streptozocin diabetic rats.

Authors:  A Kernell; H Dahlkvist; H Arnqvist; J Ludvigsson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1985       Impact factor: 3.117

3.  Retinal microangiopathy and pigment epithelial lesions in subjects with normal, borderline, and decreased oral glucose tolerance.

Authors:  P Algvere; S Efendić; R Luft; A Wajngot
Journal:  Br J Ophthalmol       Date:  1985-06       Impact factor: 4.638

4.  Ocular complications in the old and glucose-intolerant genetically obese (fa/fa) rat.

Authors:  A Dosso; E Rungger-Brändle; F Rohner-Jeanrenaud; E Ionescu; C Guillaume-Gentil; B Jeanrenaud; P M Leuenberger
Journal:  Diabetologia       Date:  1990-03       Impact factor: 10.122

5.  Sequential vitreous fluorophotometry in diabetes mellitus: a five-year prospective study.

Authors:  S R Waltman
Journal:  Trans Am Ophthalmol Soc       Date:  1984

6.  Permeability of blood-retinal barriers in urethane-induced rat retinopathy: a fluorescein angiographic, vitreous fluorophotometric, and fluorescence microscopic study.

Authors:  E E Kritzinger; R W Bellhorn
Journal:  Br J Ophthalmol       Date:  1982-10       Impact factor: 4.638

7.  Vitreous fluorescein accumulation determined by in vivo fluorophotometry and by vitreous extraction in normal and diabetic rats.

Authors:  F Kaufmann; C Lacoste
Journal:  Diabetologia       Date:  1986-03       Impact factor: 10.122

8.  Disruption of iridial blood-aqueous barrier in experimental diabetic rats.

Authors:  T Ishibashi; K Tanaka; Y Taniguchi
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1982       Impact factor: 3.117

9.  Blood-retinal barriers in juvenile diabetics in relation to early clinical manifestations, HLA-DR types, and metabolic control.

Authors:  A Kernell; J Ludvigsson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1985       Impact factor: 3.117

10.  Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats.

Authors:  Amporn Jariyapongskul; Chonticha Areebambud; Sunit Suksamrarn; Chantana Mekseepralard
Journal:  Biomed Res Int       Date:  2015-04-09       Impact factor: 3.411
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