Literature DB >> 6558078

HLA-Dw1 and BfF as protective markers in multiple sclerosis.

J Ilonen, A Lagerstedt, S Koskimies, M Reunanen.   

Abstract

The frequencies of Properdin factor B allotypes were studied in 54 multiple sclerosis patients and 58 healthy control subjects, and the association of various phenotypes with HLA-Dw1 and Dw2 antigens (found with decreased and increased frequency in MS patients, respectively) was further studied. SS genotype was found in 76% of MS patients and 63% of control subjects (n.s.) F types (FS + FF) were found to be strongly associated with HLA-Dw1 in control subjects (P less than 0.0014), whereas neither SS nor F containing types were associated with Dw2. The findings support the concept of a hypothetical MS resistance factor in the HLA gene area.

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Year:  1983        PMID： 6558078     DOI： 10.1016/0165-5728(83)90048-6

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  7 in total

1.  Defective autologous mixed leukocyte reaction in newly diagnosed type 1 diabetes mellitus.

Authors:  L Räsänen; H Hyöty; M Lehto; O P Kallioniemi; J Antonen; T Huupponen; J Karjalainen; P Leinikki
Journal:  Clin Exp Immunol       Date:  1988-03       Impact factor: 4.330

2.  HLA and prognosis in multiple sclerosis.

Authors:  B Runmarker; T Martinsson; J Wahlström; O Andersen
Journal:  J Neurol       Date:  1994-05       Impact factor: 4.849

3.  An analysis of epidemiological data in HLA-typed diabetic children.

Authors:  A Mustonen; J Ilonen; A Tiilikainen; M Kataja; H K Akerblom
Journal:  Diabetologia       Date:  1985-07       Impact factor: 10.122

4.  Differences in HLA antigens between patients with mixed connective tissue disease and systemic lupus erythematosus.

Authors:  P Ruuska; R Hämeenkorpi; S Forsberg; H Julkunen; R Mäkitalo; J Ilonen; A Tiilikainen
Journal:  Ann Rheum Dis       Date:  1992-01       Impact factor: 19.103

5.  Only high disease activity and positive rheumatoid factor indicate poor prognosis in patients with early rheumatoid arthritis treated with "sawtooth" strategy.

Authors:  T Möttönen; L Paimela; M Leirisalo-Repo; H Kautiainen; J Ilonen; P Hannonen
Journal:  Ann Rheum Dis       Date:  1998-09       Impact factor: 19.103

6.  Lymphocyte subpopulations at the onset of type 1 (insulin-dependent) diabetes.

Authors:  J Ilonen; H M Surcel; A Mustonen; M L Käär; H K Akerblom
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122

7.  Association of different HLA antigens with various toxic effects of gold salts in rheumatoid arthritis.

Authors:  M Hakala; A H van Assendelft; J Ilonen; S Jalava; A Tiilikainen
Journal:  Ann Rheum Dis       Date:  1986-03       Impact factor: 19.103
  7 in total

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