Literature DB >> 6554026

Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes).

C A Alper, D Raum, S Karp, Z L Awdeh, E J Yunis.   

Abstract

The loci for the complement proteins C2 and BF, and the two loci for C4 are closely linked to one another. In many hundreds of meioses no crossing over has been detected between these loci. In addition, the alleles of these four loci occur in specific combinations not predicted by their gene frequencies in much the same way as alleles of the Rh and MNS systems. These units are termed complotypes. There are 14 complotypes with frequencies in excess of 1% in our study population of normal sixth chromosomes from Caucasians. Since they are also intimately associated with HLA-DR, comploytypes may also be of importance in screening programs for transplantation.

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Year:  1983        PMID： 6554026     DOI： 10.1111/j.1423-0410.1983.tb04124.x

Source DB:  PubMed          Journal:  Vox Sang        ISSN： 0042-9007            Impact factor:   2.144


  42 in total

1.  HLADR5 and C4BQO high frequency and antinuclear antibodies positivity in patients with 21 hydroxylase deficiency from Campania region.

Authors:  F Parlato; G Pisano; G Misiano; E Cosentini; C Cacciapuoti; M R Cavalcanti; M Brai; A Bellastella
Journal:  J Endocrinol Invest       Date:  1992-06       Impact factor: 4.256

2.  A restriction fragment of the C2 gene is a unique marker for C2 deficiency and the uncommon C2 allele C2*B (a marker for type 1 diabetes).

Authors:  S Simon; Z Awdeh; R D Campbell; P Ronco; S J Brink; G S Eisenbarth; E J Yunis; C A Alper
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

3.  Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris.

Authors:  A R Ahmed; R Wagner; K Khatri; G Notani; Z Awdeh; C A Alper; E J Yunis
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

4.  The cellular basis for lack of antibody response to hepatitis B vaccine in humans.

Authors:  E Egea; A Iglesias; M Salazar; C Morimoto; M S Kruskall; Z Awdeh; S F Schlossman; C A Alper; E J Yunis
Journal:  J Exp Med       Date:  1991-03-01       Impact factor: 14.307

5.  Complotypes in individuals of African origin: frequencies and possible extended MHC haplotypes.

Authors:  P A Fraser; B Moore; R Stein; S Alosco; A H Johnson; D Marcus-Bagley; Z Awdeh; E J Yunis; C A Alper
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

6.  Polymorphism of MHC class III genes: definition of restriction fragment linkage groups and evidence for frequent deletions and duplications.

Authors:  N Ghanem; B Uring-Lambert; M Abbal; G Hauptmann; M P Lefranc; G Lefranc
Journal:  Hum Genet       Date:  1988-07       Impact factor: 4.132

7.  Analysis of HLA-B35 variants and B35 haplotypes by isoelectric focusing and Southern blot analysis.

Authors:  E Lederer; E Nössner; R Wank; D J Schendel
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

8.  Quantitative variation of C4 variant proteins associated with many MHC haplotypes.

Authors:  L Truedsson; Z Awdeh; E J Yunis; S Mrose; B Moore; C A Alper
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

9.  Human C4 polymorphism: pedigree analysis of qualitative, quantitative, and functional parameters as a basis for phenotype interpretations.

Authors:  G Mauff; K Bender; C M Giles; S Goldmann; W Opferkuch; B Wachauf
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy.

Authors:  C A Alper; E Fleischnick; Z Awdeh; A J Katz; E J Yunis
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808
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