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Literature DB >> 6551102

Isoelectrofocusing in the study of the Bf system: existence of two common subtypes of the BfF allele.

G Geserick, D Patzelt, H Schröder, T Nagai.

Abstract

The inherited polymorphism of the properdin factor B (Bf system) was studied by isoelectrofocusing in polyacrylamide gel (PAGIF, pH range 5.0-8.0), followed by immunofixation. Using the described technique, two different subtypes of F bands are visible (designated as F' and F"). Studies of 13 families and 48 mother-child pairs are not in contradiction to the assumption of a codominant inheritance by two alleles (BfF' and BfF") at a single locus.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6551102 DOI： 10.1111/j.1423-0410.1983.tb01882.x

Source DB: PubMed Journal: Vox Sang ISSN： 0042-9007 Impact factor: 2.144

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Cited

13 in total

1. Apparently non-expressed alleles of factor B (BF) code for hypomorphic proteins.

Authors: I Siemens; M Brenden; G Mauff; M Abbal; E Du Toit; J Bertrams; G Geserick
Journal: Immunogenetics Date: 1992 Impact factor: 2.846

2. Nomenclature for human complement factor B. WHO-IUIS Nomenclature Sub-Committee.

Authors:
Journal: Bull World Health Organ Date: 1992 Impact factor: 9.408

3. Polymorphism of MHC class III genes: definition of restriction fragment linkage groups and evidence for frequent deletions and duplications.

Authors: N Ghanem; B Uring-Lambert; M Abbal; G Hauptmann; M P Lefranc; G Lefranc
Journal: Hum Genet Date: 1988-07 Impact factor: 4.132

9. Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the Bf/C2 gene family.

Authors: David P Terwilliger; Lori A Clow; Paul S Gross; L Courtney Smith
Journal: Immunogenetics Date: 2004-09-22 Impact factor: 2.846

10. A new BF F variant by polyacrylamide gel isoelectric focusing.

Authors: S Nakamura; O Ohue; K Abe
Journal: Hum Genet Date: 1987-11 Impact factor: 4.132

Isoelectrofocusing in the study of the Bf system: existence of two common subtypes of the BfF allele.

1. Apparently non-expressed alleles of factor B (BF) code for hypomorphic proteins.

2. Nomenclature for human complement factor B. WHO-IUIS Nomenclature Sub-Committee.

3. Polymorphism of MHC class III genes: definition of restriction fragment linkage groups and evidence for frequent deletions and duplications.

4. The position of the gene locus for monocyte alloantigens (HMA system) on chromosome 6.

5. Factor B subtyping in sera and bloodstains by isoelectric focusing and immunoblotting.

6. Human BF*F-subtypes: segregation analysis with inclusion of MHC haplotypes.

7. Molecular characterization of human complement factor B subtypes.

8. Genetic polymorphism and linkage of the sixth and seventh complement components (C6 and C7) in the common marmoset.

9. Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the Bf/C2 gene family.

10. A new BF F variant by polyacrylamide gel isoelectric focusing.