Literature DB >> 6550535

New low-molecular inhibitors of pancreatic elastase with possible in vivo application: alkylamides of N-acylated tripeptides.

P Fric, E Kasafírek, J Slabý.   

Abstract

Out of a series of alkylamides of N-acylated tripeptides, Glt-(Ala)2-Pro-NH-Et and Glt-(Ala)3-NH-Pr were found to be potent inhibitors of porcine and human pancreatic elastase, and because they are free of toxic groups they might be considered for in vivo application.

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Year:  1983        PMID： 6550535     DOI： 10.1007/bf01963130

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Elastolytic activity of human duodenal contents.

Authors:  P Fric; J Slabý; E Kasafírek; F Malis
Journal:  Clin Chim Acta       Date:  1975-09-16       Impact factor: 3.786

2.  Restrictions on the binding of proline-containing peptides to elastase.

Authors:  R C Thompson; E R Blout
Journal:  Biochemistry       Date:  1973-01-02       Impact factor: 3.162

3.  The significance of the N-acyl residue of L-alanyl-L-alanyl-L-alanine p-nitroanilide for cleavage by pancreatic elastase.

Authors:  E Kasafírek; P Fric; F Malis
Journal:  FEBS Lett       Date:  1974-04-01       Impact factor: 4.124

4.  On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain.

Authors:  I Schechter; A Berger
Journal:  Biochem Biophys Res Commun       Date:  1968-09-06       Impact factor: 3.575

5.  p-Nitroanilides of 3-carboxypropionyl-peptides. Their cleavage by elastase, trypsin, and chymotrypsin.

Authors:  E Kasafírek; P Fric; J Slabý; F Malis
Journal:  Eur J Biochem       Date:  1976-10-01
  5 in total
  1 in total

1.  Effective peritoneal therapy of acute pancreatitis in the rat with glutaryl-trialanin-ethylamide: a novel inhibitor of pancreatic elastase.

Authors:  P Fric; J Slabý; E Kasafírek; P Kocna; J Marek
Journal:  Gut       Date:  1992-05       Impact factor: 23.059
  1 in total

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