Literature DB >> 6549413

VIP and PHI coexist with an NPY-like peptide in intramural neurones of the small intestine.

E Ekblad, R Håkanson, F Sundler.   

Abstract

Vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are neuropeptides present in all layers of the small intestine. NPY-immunoreactive fibres in the gut seem to derive from two sources. One population is of extramural (sympathetic) origin and contains noradrenaline, another is of intramural origin and does not contain noradrenaline. In the present study of mouse, rat and pig, immunocytochemistry showed immunoreactive PHI to coexist completely with immunoreactive VIP. This was predictable, since VIP and PHI derive from the same precursor. In addition, however, VIP and PHI were found to coexist with immunoreactive NPY in non-adrenergic (but not in adrenergic) nerve fibres and nerve cell bodies. This coexistence was unexpected, since the VIP precursor does not contain NPY-like sequences.

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Year:  1984        PMID： 6549413     DOI： 10.1016/0167-0115(84)90052-1

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  20 in total

1.  Vasoactive intestinal polypeptide and acetylcholine coexist with neuropeptide Y, dopamine-beta-hydroxylase, tyrosine hydroxylase, substance P or calcitonin gene-related peptide in neuronal subpopulations in cranial parasympathetic ganglia of rat.

Authors:  J E Hardebo; N Suzuki; E Ekblad; C Owman
Journal:  Cell Tissue Res       Date:  1992-02       Impact factor: 5.249

2.  Role of acetylcholine and gastrin-releasing peptide (GRP) in gastrin secretion.

Authors:  M Matsuno; T Matsui; A Iwasaki; Y Arakawa
Journal:  J Gastroenterol       Date:  1997-10       Impact factor: 7.527

3.  Peptide-containing nerve fibers in the respiratory tract of the ferret.

Authors:  A Luts; F Sundler
Journal:  Cell Tissue Res       Date:  1989-11       Impact factor: 5.249

4.  Intramural distribution of regulatory peptides in the sigmoid-recto-anal region of the human gut.

Authors:  G L Ferri; T E Adrian; J M Allen; L Soimero; A Cancellieri; J C Yeats; M Blank; J M Polak; S R Bloom
Journal:  Gut       Date:  1988-06       Impact factor: 23.059

5.  Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy.

Authors:  P Alm; L M Lundberg
Journal:  Cell Tissue Res       Date:  1988       Impact factor: 5.249

6.  Vasoactive intestinal polypeptide-like immunoreactivity in the bovine heart: high degree of coexistence with neuropeptide Y-like immunoreactivity.

Authors:  S Forsgren
Journal:  Cell Tissue Res       Date:  1989-04       Impact factor: 5.249

7.  Neuropeptide Y antagonises secretagogue evoked chloride transport in rat jejunal epithelium.

Authors:  H M Cox; A W Cuthbert
Journal:  Pflugers Arch       Date:  1988-11       Impact factor: 3.657

8.  Neuropeptides and the microcircuitry of the enteric nervous system.

Authors:  I J Llewellyn-Smith
Journal:  Experientia       Date:  1987-07-15

9.  Existence and coexistence of peptides in nerves of the mammalian ovary and oviduct demonstrated by immunocytochemistry.

Authors:  P Kannisto; E Ekblad; G Helm; C Owman; N O Sjöberg; M Stjernquist; F Sundler; B Walles
Journal:  Histochemistry       Date:  1986

10.  Immunohistochemical localization of neuropeptide Y in the guinea pig medulla oblongata. Correlation with VIP and DBH.

Authors:  X L Dai; J Triepel; C Heym
Journal:  Histochemistry       Date:  1986
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