Literature DB >> 6548977

Hb Marseille [alpha 2 beta 2 N methionyl-2 (NA2) His----Pro]: a new beta chain variant having an extended N-terminus.

Y Blouquit, N Arous, D Lena, J Delanoe-Garin, C Lacombe, J Bardakdjian, L Vovan, A Orsini, J Rosa, F Galacteros.   

Abstract

A new abnormal hemoglobin was found in a diabetic Maltese woman by citrate agar electrophoresis. This variant was undetectable by isoelectric focusing. No hematological abnormalities were observed. The structural analysis included isolation of the abnormal beta chain, high pressure liquid chromatography of the corresponding tryptic peptides and then microsequencing of the abnormal T1. These procedures revealed a double abnormality: the presence of a methionyl residue extending the NH2 terminus and a histidine to proline substitution in position NA2.

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Year:  1984        PMID： 6548977     DOI： 10.1016/0014-5793(84)80624-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  The linkage of Hb Valletta [alpha 2 beta 287(f3)Thr----Pro] and Hb F-Malta-I [alpha 2G gamma 2117(G19)His----Arg] in the Maltese population.

Authors:  F Kutlar; A E Felice; J L Grech; W H Bannister; A Kutlar; J B Wilson; B B Webber; H Y Hu; T H Huisman
Journal:  Hum Genet       Date:  1991-04       Impact factor: 4.132

2.  Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation.

Authors:  J P Boissel; T J Kasper; S C Shah; J I Malone; H F Bunn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

3.  Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.

Authors:  D L Diuguid; M J Rabiet; B C Furie; H A Liebman; B Furie
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

Review 4.  N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects.

Authors:  Sylvia Varland; Camilla Osberg; Thomas Arnesen
Journal:  Proteomics       Date:  2015-06-16       Impact factor: 3.984
  4 in total

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