Literature DB >> 6548911

Enhancement of amphotericin B selectivity by antibiotic incorporation into gel state vesicles. A circular dichroism and permeability study.

A Vertut-Croquin, J Bolard, C M Gary-Bobo.   

Abstract

The permeability induced in cholesterol-or ergosterol-containing phospholipid vesicles by Amphotericin B incorporated into Dipalmitoyl Phosphatidylcholine vesicles has been studied in parallel with Circular Dichroism spectroscopy measurements. In our conditions, Amphotericin B is 5 to 10 times more selective to ergosterol- than to cholesterol-containing vesicles. Such a large difference is not observed when Amphotericin B is directly added to the vesicles suspension as its solution in organic solvent.

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Year:  1984        PMID： 6548911     DOI： 10.1016/s0006-291x(84)80376-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

Review 1.  Carrier effects on biological activity of amphotericin B.

Authors:  J Brajtburg; J Bolard
Journal:  Clin Microbiol Rev       Date:  1996-10       Impact factor: 26.132

2.  Cooperative partition model of nystatin interaction with phospholipid vesicles.

Authors:  Ana Coutinho; Manuel Prieto
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033

3.  Transfer of amphotericin B from gel state vesicles to mycoplasma cells: biphasic action on potassium transport and permeability.

Authors:  A Vertut-Croquin; J Bolard; C M Gary-Bobo
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

4.  Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits.

Authors:  M H Koldin; G S Kobayashi; J Brajtburg; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1985-07       Impact factor: 5.191

5.  Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study.

Authors:  Yuichi Umegawa; Tomoya Yamamoto; Mayank Dixit; Kosuke Funahashi; Sangjae Seo; Yasuo Nakagawa; Taiga Suzuki; Shigeru Matsuoka; Hiroshi Tsuchikawa; Shinya Hanashima; Tohru Oishi; Nobuaki Matsumori; Wataru Shinoda; Michio Murata
Journal:  Sci Adv       Date:  2022-06-17       Impact factor: 14.957
  5 in total

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