Literature DB >> 6548142

Effect of oxygen-derived reactive species on cartilage proteoglycan-hyaluronate aggregates.

E J Bates, G S Harper, D A Lowther, B N Preston.   

Abstract

Proteoglycan-hyaluronate aggregates were incubated with oxygen-derived reactive species generated enzymatically by the action of xanthine oxidase upon hypoxanthine. Analysis of the products of the incubation by caesium sulphate zonal sedimentation revealed that degradation of aggregate had occurred. This effect was reversed by inclusion of superoxide dismutase, catalase or diethylenetriaminepentaacetic acid in the incubations suggesting that hydroxyl radicals were the active species. Separate analysis by gel filtration chromatography on Sepharose CL-2B of proteoglycan monomer subjected to a similar treatment indicated that the molecule is minimally degraded. These results are discussed with reference to the well established degradation of hyaluronate by oxygen-derived reactive species.

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Year:  1984        PMID： 6548142

Source DB:  PubMed          Journal:  Biochem Int        ISSN： 0158-5231


  19 in total

Review 1.  Brain extracellular space, hyaluronan, and the prevention of epileptic seizures.

Authors:  Katherine L Perkins; Amaia M Arranz; Yu Yamaguchi; Sabina Hrabetova
Journal:  Rev Neurosci       Date:  2017-11-27       Impact factor: 4.353

2.  Selective decreased de novo synthesis of glomerular proteoglycans under the influence of reactive oxygen species.

Authors:  N Kashihara; Y Watanabe; H Makino; E I Wallner; Y S Kanwar
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

3.  Degradation of human proteoglycan aggregate induced by hydrogen peroxide. Protein fragmentation, amino acid modification and hyaluronic acid cleavage.

Authors:  C R Roberts; P J Roughley; J S Mort
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

4.  Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR/OrtCrlj mice by measuring the biomarkers for oxidative stress and type II collagen degradation/synthesis.

Authors:  Taiji Watari; Kiyohito Naito; Koji Sakamoto; Hisashi Kurosawa; Isao Nagaoka; Kazuo Kaneko
Journal:  Exp Ther Med       Date:  2011-01-19       Impact factor: 2.447

5.  Hyaluronic acid in human articular cartilage. Age-related changes in content and size.

Authors:  M W Holmes; M T Bayliss; H Muir
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

6.  Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.

Authors:  Amaia M Arranz; Katherine L Perkins; Fumitoshi Irie; David P Lewis; Jan Hrabe; Fanrong Xiao; Naoki Itano; Koji Kimata; Sabina Hrabetova; Yu Yamaguchi
Journal:  J Neurosci       Date:  2014-04-30       Impact factor: 6.167

7.  Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides.

Authors:  S L Marklund; A Bjelle; L G Elmqvist
Journal:  Ann Rheum Dis       Date:  1986-10       Impact factor: 19.103

8.  Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of human neutrophils to damage human articular cartilage.

Authors:  E J Bates; I C Kowanko; A Ferrante
Journal:  Ann Rheum Dis       Date:  1988-01       Impact factor: 19.103

9.  Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma.

Authors:  Sumit Ghosh; Amali E Samarasinghe; Scott A Hoselton; Glenn P Dorsam; Jane M Schuh
Journal:  Inflamm Res       Date:  2014-02-12       Impact factor: 4.575

10.  Binding of haptoglobin, inter-alpha-trypsin inhibitor, and alpha 1 proteinase inhibitor to synovial fluid hyaluronate and the influence of these proteins on its degradation by oxygen derived free radicals.

Authors:  N Hutadilok; P Ghosh; P M Brooks
Journal:  Ann Rheum Dis       Date:  1988-05       Impact factor: 19.103
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