Literature DB >> 6547772

A spirohydantoin derivative of dimethoxytetrahydronaphthalene: an experimental anticonvulsant.

G J Alexander, B Sinha, N Chatterjie.   

Abstract

A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induced by pentylenetetrazol (Metrazol).

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Year:  1984        PMID： 6547772     DOI： 10.1007/bf00964379

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  5 in total

1.  Synthesis and anticonvulsive activity of a N-propylurea-ninhydrin condensation product in mice.

Authors:  N Chatterjie; B Sinha; G J Alexander
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1983-02

2.  Metrazol thresholds in inbred and non-inbred audiosensitive mice.

Authors:  G J Alexander; L M Kopeloff; R B Alexander
Journal:  Neurotoxicology       Date:  1981-01       Impact factor: 4.294

3.  A nonmetabolized analogue of phenytoin.

Authors:  J D Henderson; P G Dayton; Z H Israili; L Mandell
Journal:  J Med Chem       Date:  1981-07       Impact factor: 7.446

4.  Anticonvulsive activity of indenoimidazolidinones and related heterocyclic compounds in mice.

Authors:  G J Alexander; N Chatterjie
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1980-01

5.  Eboracin: a substituted indenopyrrole active against metrazol-induced, audiogenic and electroshock seizures in mice.

Authors:  G J Alexander; N Chatterjie; L M Kopeloff
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1982       Impact factor: 5.067
  5 in total
  1 in total

1.  Anticonvulsant properties of spirohydantoins derived from optical isomers of camphor.

Authors:  N Chatterjie; G J Alexander
Journal:  Neurochem Res       Date:  1986-12       Impact factor: 3.996
  1 in total

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