Literature DB >> 6547247

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.

G Petranyi, N S Ryder, A Stütz.   

Abstract

A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.

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Year:  1984        PMID： 6547247     DOI： 10.1126/science.6547247

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  59 in total

1.  Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.

Authors:  J A Urbina; K Lazardi; T Aguirre; M M Piras; R Piras
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

2.  Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.

Authors:  K Lazardi; J A Urbina; W de Souza
Journal:  Antimicrob Agents Chemother       Date:  1990-11       Impact factor: 5.191

3.  Induction and Characterization of Penicillium caseicolum Mutants Resistant to Ergosterol Biosynthesis Inhibitors.

Authors:  A de Falandre; I Bouvier-Fourcade; J M Seng; P Leroux
Journal:  Appl Environ Microbiol       Date:  1987-07       Impact factor: 4.792

Review 4.  Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors:  N H Georgopapadakou; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

5.  In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent.

Authors:  Y Niwano; N Kuzuhara; H Kodama; M Yoshida; T Miyazaki; H Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

6.  Steroids initiate a signaling cascade that triggers rapid sporulation in Dictyostelium.

Authors:  Christophe Anjard; Yongxuan Su; William F Loomis
Journal:  Development       Date:  2009-01-28       Impact factor: 6.868

7.  Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes.

Authors:  T Vago; G Baldi; D Colombo; M Barbareschi; G Norbiato; F Dallegri; M Bevilacqua
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

8.  Two mechanisms of butenafine action in Candida albicans.

Authors:  W Iwatani; T Arika; H Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

9.  Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum.

Authors:  Christine A Hodge; Vineet Choudhary; Michael J Wolyniak; John J Scarcelli; Roger Schneiter; Charles N Cole
Journal:  J Cell Sci       Date:  2010-01-01       Impact factor: 5.285

10.  Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate.

Authors:  N S Ryder; I Frank; M C Dupont
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191
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